High-speed label-free functional photoacoustic microscopy of mouse brain in action.
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2015-05
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We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.
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Yao, Junjie, Lidai Wang, Joon-Mo Yang, Konstantin I Maslov, Terence TW Wong, Lei Li, Chih-Hsien Huang, Jun Zou, et al. (2015). High-speed label-free functional photoacoustic microscopy of mouse brain in action. Nat Methods, 12(5). pp. 407–410. 10.1038/nmeth.3336 Retrieved from https://hdl.handle.net/10161/12773.
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