B-cell targeting in chronic Graft-versus-Host disease.

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2018-02-01

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Abstract

Over the last decade our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B-cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B-cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.

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Published Version (Please cite this version)

10.1182/blood-2017-11-784017

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Zeiser, Robert, Stefanie Sarantopoulos and Bruce R Blazar (2018). B-cell targeting in chronic Graft-versus-Host disease. Blood. 10.1182/blood-2017-11-784017 Retrieved from https://hdl.handle.net/10161/16092.

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