Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition.

dc.contributor.author

Larrauri, José A

dc.contributor.author

Kelley, Lisalynn D

dc.contributor.author

Jenkins, Mason R

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Westman, Eric C

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Schmajuk, Nestor A

dc.contributor.author

Rosenthal, M Zachary

dc.contributor.author

Levin, Edward D

dc.date.accessioned

2024-08-01T13:46:41Z

dc.date.available

2024-08-01T13:46:41Z

dc.date.issued

2014-02

dc.description.abstract

Histamine H1 receptor systems have been shown in animal studies to have important roles in the reversal of sensorimotor gating deficits, as measured by prepulse inhibition (PPI). H1-antagonist treatment attenuates the PPI impairments caused by either blockade of NMDA glutamate receptors or facilitation of dopamine transmission. The current experiment brought the investigation of H1 effects on sensorimotor gating to human studies. The effects of the histamine H1 antagonist meclizine on the startle response and PPI were investigated in healthy male subjects with high baseline startle responses and low PPI levels. Meclizine was administered to participants (n=24) using a within-subjects design with each participant receiving 0, 12.5, and 25 mg of meclizine in a counterbalanced order. Startle response, PPI, heart rate response, galvanic skin response, and changes in self-report ratings of alertness levels and affective states (arousal and valence) were assessed. When compared with the control (placebo) condition, the two doses of meclizine analyzed (12.5 and 25 mg) produced significant increases in PPI without affecting the magnitude of the startle response or other physiological variables. Meclizine also caused a significant increase in overall self-reported arousal levels, which was not correlated with the observed increase in PPI. These results are in agreement with previous reports in the animal literature and suggest that H1 antagonists may have beneficial effects in the treatment of subjects with compromised sensorimotor gating and enhanced motor responses to sensory stimuli.

dc.identifier

npp2013248

dc.identifier.issn

0893-133X

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1740-634X

dc.identifier.uri

https://hdl.handle.net/10161/31298

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

dc.relation.isversionof

10.1038/npp.2013.248

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Humans

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Meclizine

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Histamine H1 Antagonists

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Acoustic Stimulation

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Double-Blind Method

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Galvanic Skin Response

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Heart Rate

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Neural Inhibition

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Dose-Response Relationship, Drug

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Adolescent

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Adult

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Female

dc.subject

Male

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Sensory Gating

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Young Adult

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Self Report

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Reflex, Startle

dc.title

Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition.

dc.type

Journal article

duke.contributor.orcid

Levin, Edward D|0000-0002-5060-9602

pubs.begin-page

651

pubs.end-page

659

pubs.issue

3

pubs.organisational-group

Duke

pubs.organisational-group

Nicholas School of the Environment

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School of Medicine

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Trinity College of Arts & Sciences

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Faculty

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Pharmacology & Cancer Biology

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Medicine

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Psychiatry & Behavioral Sciences

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Medicine, General Internal Medicine

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Duke Cancer Institute

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Psychology & Neuroscience

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Environmental Sciences and Policy

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University Initiatives & Academic Support Units

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University Institutes and Centers

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Duke Institute for Brain Sciences

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Initiatives

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Duke Science & Society

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Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

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Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology

pubs.publication-status

Published

pubs.volume

39

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