PROMIS CAT Outperforms Legacy Measures and Demonstrates Patient Health Domain Normalization at Minimum Two-Year Follow-Up After Adult Spine Deformity Surgery.

Abstract

Study designProspective, multi-center analysis.ObjectiveEvaluate preoperative and minimum 2-year postoperative health related quality of life (HRQOL) outcomes for adult spine deformity (ASD) using legacy HRQOL measures and computer adaptive testing (CAT) version of the patient reported outcome measurement information system (PROMIS).Summary of background dataPROMIS is the NIH recommended measure for patient reported outcomes. No data exists evaluating minimum 2-year ASD surgical outcomes using PROMIS CAT compared to legacy HRQOL measures.MethodsASD patients > 18 years of age were enrolled into a prospective, multi-center, observational study. Patients were administered legacy HRQOLs (SRS-22r, ODI, NRS back and leg pain, VR-12) and PROMIS CAT for Pain Interference, Physical Function, Satisfaction with Participation in Social Roles, Satisfaction with Participation in Discretionary Social Activities, Depression, and Anxiety. Preoperative and minimum 2-year postoperative HRQOL scores were compared and ASD PROMIS scores were compared to general population PROMIS values.Results144 of 190 patients had complete data at minimum 2-year follow-up. Mean preoperative values included: age=62.6 years, scoliosis=34.2°, SVA=74.2mm, PI-LL=16.7. At mean 2.3 year follow-up surgical treatment improved spine alignment (scoliosis=14.7°, SVA=34.5mm, and PI-LL=4.5°; P<0.0001). All legacy HRQOL and PROMIS scores improved from preoperative to minimum 2-year postoperative (P<0.005). Referencing PROMIS scores to normative values demonstrated 50-85% of ASD patients preoperatively reported moderate-severe deficits in all domains. At minimum 2-year postoperative 52-88% of ASD patients reported normal values-mild deficits in all PROMIS domains. PROMIS social health domains demonstrated the greatest improvement.ConclusionThis is the first study evaluating minimum 2-year ASD surgical outcomes using PROMIS CAT. ASD patients demonstrated postoperative improvements in all PROMIS health domains, with the social health domains improving most. The majority of ASD patients reported normal PROMIS values at minimum 2-years postoperative.