Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.

Melton, M Stephen

Browndyke, Jeffrey N

Harshbarger, Todd B

Madden, David J

Nielsen, Karen C

Klein, Stephen M

United States

2016-08-01T14:48:26Z

2018-01-03T16:16:45Z

2018-01-03T16:16:45Z

2016-08

BACKGROUND: Limited information exists on the effects of temporary functional deafferentation (TFD) on brain activity after peripheral nerve block (PNB) in healthy humans. Increasingly, resting-state functional connectivity (RSFC) is being used to study brain activity and organization. The purpose of this study was to test the hypothesis that TFD through PNB will influence changes in RSFC plasticity in central sensorimotor functional brain networks in healthy human participants. METHODS: The authors achieved TFD using a supraclavicular PNB model with 10 healthy human participants undergoing functional connectivity magnetic resonance imaging before PNB, during active PNB, and during PNB recovery. RSFC differences among study conditions were determined by multiple-comparison-corrected (false discovery rate-corrected P value less than 0.05) random-effects, between-condition, and seed-to-voxel analyses using the left and right manual motor regions. RESULTS: The results of this pilot study demonstrated disruption of interhemispheric left-to-right manual motor region RSFC (e.g., mean Fisher-transformed z [effect size] at pre-PNB 1.05 vs. 0.55 during PNB) but preservation of intrahemispheric RSFC of these regions during PNB. Additionally, there was increased RSFC between the left motor region of interest (PNB-affected area) and bilateral higher order visual cortex regions after clinical PNB resolution (e.g., Fisher z between left motor region of interest and right and left lingual gyrus regions during PNB, -0.1 and -0.6 vs. 0.22 and 0.18 after PNB resolution, respectively). CONCLUSIONS: This pilot study provides evidence that PNB has features consistent with other models of deafferentation, making it a potentially useful approach to investigate brain plasticity. The findings provide insight into RSFC of sensorimotor functional brain networks during PNB and PNB recovery and support modulation of the sensory-motor integration feedback loop as a mechanism for explaining the behavioral correlates of peripherally induced TFD through PNB.

https://www.ncbi.nlm.nih.gov/pubmed/27272674

1528-1175

https://hdl.handle.net/10161/15957

eng

Ovid Technologies (Wolters Kluwer Health)

Anesthesiology

10.1097/ALN.0000000000001198

http://hdl.handle.net/10161/12541

10161/12541

Adult

Brain

Female

Functional Laterality

Humans

Magnetic Resonance Imaging

Male

Motor Cortex

Nerve Block

Nerve Net

Neuroimaging

Neuronal Plasticity

Peripheral Nerves

Pilot Projects

Rest

Sensorimotor Cortex

Visual Cortex

Young Adult

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.

Journal article

Browndyke, Jeffrey N|0000-0002-8573-7073

Harshbarger, Todd B|0000-0001-5030-465X

Madden, David J|0000-0003-2815-6552

https://www.ncbi.nlm.nih.gov/pubmed/27272674

368

377

2

Anesthesiology

Anesthesiology, Ambulatory

Center for Cognitive Neuroscience

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke-UNC Center for Brain Imaging and Analysis

Institutes and Centers

Institutes and Provost's Academic Units

Psychiatry & Behavioral Sciences

Psychiatry & Behavioral Sciences, Geriatric Behavioral Health

Psychology and Neuroscience

Radiology

School of Medicine

Temp group - logins allowed

Trinity College of Arts & Sciences

University Institutes and Centers

Published

125