Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19.

Clinical Anesthesia
My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery.

I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of peripheral nerve blocks and have lectured on several national courses.

Human Pharmacology & Physiology Lab (HPPL)
I am the Director of the HPPL which is the the Department of Anesthesiology's clinical research lab designed to conduct studies in healthy volunteers. It is designed to collect comprehensive physiological data in a manner similar to the Operating Room (OR), using both non-invasive and invasive techniques. The key areas of interest are:

• Early human clinical drug trials (Phase 1 & 2) of drugs related to anesthesia
• Conduct of clinical equipment validation studies prior to FDA approval

Paul Wischmeyer, MD, EDIC, FASPEN, FCCM is a nutrition, exercise, critical care, and perioperative physician-researcher who specializes in enhancing preparation and recovery from surgery, critical care and COVID-19. He serves as a Tenured Professor of Anesthesiology and Surgery at Duke. He also serves as the Director of the Duke Clinical Nutrition Fellowship, Director of the TPN/Nutrition Team at Duke and Director of The DUKE STRONGER Prehab/Rehab Service- Surgical and ICU Therapy for Rehabilitation, Optimization, Nutrition, Growth (Muscle), Endurance, and Recovery (STRONGER) Service/Clinic. The Duke STRONGER service and clinic is a unique multi-disciplinary initiative focused on helping surgical, organ transplant, cancer, and ICU patients regain strength, muscle, endurance, nutrition status, and cognition via use of personalized nutrition, exercise and anabolic agent/nutrient interventions— before, during and after their hospital journey. Its focus is on how we help our patients not just survive, but recover stronger.

Dr. Wischmeyer earned his medical degree with honors at The University of Chicago Pritzker School of Medicine, where he was elected into the honor society of Alpha Omega Alpha for outstanding academic achievement. He completed his pediatric internship at University of Colorado Children’s Hospital and his anesthesiology/critical care residency training at the University of Chicago. He also completed a Clinical Pharmacology fellowship and the NIH K30 Clinical Research Scientist Training Program while at University of Chicago.

Dr. Wischmeyer’s clinical and research focus is on helping patients prepare and recover from critical illness, injury, and surgery. His research interests include personalized surgical and ICU nutrition and exercise rehabilitation therapy, oral, enteral, and parenteral nutrition and personalized nutrition-intervention trials, perioperative optimization, post-illness muscle mass and functional recovery, and role of probiotics/microbiome in illness. Dr. Wischmeyer’s research group has been awarded multiple NIH, DOD, and other peer-reviewed grants to perform research ranging from basic mechanistic cell work to large-scale multi-center clinical trials in the fields of critical care, perioperative medicine, nutrition, illness metabolism, microbiome/probiotics, and exercise interventions to improve functional outcomes. For his research work and clinical work, Dr. Wischmeyer has received numerous awards from national and international societies including, The Jeffrey Silverstein Award and Memorial Lecture for Humanism in Medicine from the American Delirium Society, The John M. Kinney Award for the most significant contribution to field of general nutrition, the Stanley Dudrick Research Scholar Award and the 2025 Bruce Bistrian Award for Clinical Nutrition Mentorship by the American Society for Parenteral and Enteral Nutrition and The Lifetime Achievement Award of the International Parenteral Nutrition Society (IPENEMA) for significant contributions to the field of nutrition. Dr. Wischmeyer has over 260 peer-reviewed publications in critical care, anesthesiology, and nutrition, including in the New England Journal of Medicine. Finally, he has been an invited speaker at numerous national and international medical meetings delivering over 1000 invited presentations over his career. He has an H-index of 80 with over 21,500 citations to his work, including 1 publication with > 1000 citations and >25 papers with >200 citations, and >65 publications with > 100 citations. He is also the founder and Director of the Duke Online Clinical Nutrition Fellowship, an international fellowship to provide clinical nutrition training to healthcare providers worldwide, as well as unique scholarship opportunities for healthcare providers in developing nations.

Dr. Wischmeyer passion for helping patients recover from illness and surgery arises from his personal experiences as both doctor and patient in the ICU. Dr. Wischmeyer has undergone over 27 major surgeries and personally experienced multiple ICU stays due to a childhood GI illness that took more than half of his intestinal tract. Thus, preparation for surgery/critical care and recovery from illness are a way of life for Dr. Wischmeyer that he is passionate about teaching his patients and other caregivers worldwide.