Functional outcome measures in a surgical model of hip osteoarthritis in dogs.

Little, Dianne

Johnson, Stephen

Hash, Jonathan

Olson, Steven A

Estes, Bradley T

Moutos, Franklin T

Lascelles, B Duncan X

Guilak, Farshid

Germany

2017-02-24T19:03:05Z

2017-02-24T19:03:05Z

2016-12

BACKGROUND: The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal model and to evaluate functional and end-point outcome measures. METHODS: Seven dogs were subjected to partial surgical debridement of cartilage from one femoral head. Pre- and postoperative pain and functional scores, gait analysis, radiographs, accelerometry, goniometry and limb circumference were evaluated through a 20-week recovery period, followed by histological evaluation of cartilage and synovium. RESULTS: Animals developed histological and radiographic evidence of osteoarthritis, which was correlated with measurable functional impairment. For example, Mankin scores in operated limbs were positively correlated to radiographic scores but negatively correlated to range of motion, limb circumference and 20-week peak vertical force. CONCLUSIONS: This study demonstrates that multiple relevant functional outcome measures can be used successfully in a large laboratory animal model of hip osteoarthritis. These measures could be used to evaluate relative efficacy of therapeutic interventions relevant to human clinical care.

https://www.ncbi.nlm.nih.gov/pubmed/27525982

10.1186/s40634-016-0053-5

https://hdl.handle.net/10161/13676

eng

Springer Science and Business Media LLC

J Exp Orthop

10.1186/s40634-016-0053-5

Articular cartilage repair

Collagen

Inflammation

Pain

Proteoglycan

Synovium

Tissue engineering

Functional outcome measures in a surgical model of hip osteoarthritis in dogs.

Journal article

Olson, Steven A|0000-0003-2236-0667

https://www.ncbi.nlm.nih.gov/pubmed/27525982

17

1

Clinical Science Departments

Duke

Orthopaedics

School of Medicine

Published

3