A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice.

dc.contributor.author

Chabout, Jonathan

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Sarkar, Abhra

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Patel, Sheel R

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Radden, Taylor

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Dunson, David B

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Fisher, Simon E

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Jarvis, Erich D

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Switzerland

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2017-10-01T21:14:43Z

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2017-10-01T21:14:43Z

dc.date.issued

2016

dc.description.abstract

Development of proficient spoken language skills is disrupted by mutations of the FOXP2 transcription factor. A heterozygous missense mutation in the KE family causes speech apraxia, involving difficulty producing words with complex learned sequences of syllables. Manipulations in songbirds have helped to elucidate the role of this gene in vocal learning, but findings in non-human mammals have been limited or inconclusive. Here, we performed a systematic study of ultrasonic vocalizations (USVs) of adult male mice carrying the KE family mutation. Using novel statistical tools, we found that Foxp2 heterozygous mice did not have detectable changes in USV syllable acoustic structure, but produced shorter sequences and did not shift to more complex syntax in social contexts where wildtype animals did. Heterozygous mice also displayed a shift in the position of their rudimentary laryngeal motor cortex (LMC) layer-5 neurons. Our findings indicate that although mouse USVs are mostly innate, the underlying contributions of FoxP2 to sequencing of vocalizations are conserved with humans.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/27812326

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1662-5153

dc.identifier.uri

https://hdl.handle.net/10161/15592

dc.language

eng

dc.publisher

Frontiers Media SA

dc.relation.ispartof

Front Behav Neurosci

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10.3389/fnbeh.2016.00197

dc.subject

FoxP2

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KE family

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song

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speech apraxia

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syntax

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ultrasonic vocalizations

dc.title

A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice.

dc.type

Journal article

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/27812326

pubs.begin-page

197

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Basic Science Departments

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Duke

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Duke Institute for Brain Sciences

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Electrical and Computer Engineering

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Institutes and Provost's Academic Units

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Neurobiology

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Pratt School of Engineering

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School of Medicine

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Statistical Science

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Trinity College of Arts & Sciences

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University Institutes and Centers

pubs.publication-status

Published online

pubs.volume

10

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