Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.

dc.contributor.author

Jenista, Elizabeth R

dc.contributor.author

Stokes, Ashley M

dc.contributor.author

Branca, Rosa Tamara

dc.contributor.author

Warren, Warren S

dc.coverage.spatial

United States

dc.date.accessioned

2011-04-15T16:46:39Z

dc.date.issued

2009-11-28

dc.description.abstract

A recent quantum computing paper (G. S. Uhrig, Phys. Rev. Lett. 98, 100504 (2007)) analytically derived optimal pulse spacings for a multiple spin echo sequence designed to remove decoherence in a two-level system coupled to a bath. The spacings in what has been called a "Uhrig dynamic decoupling (UDD) sequence" differ dramatically from the conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo sequence. The UDD sequence was derived for a model that is unrelated to magnetic resonance, but was recently shown theoretically to be more general. Here we show that the UDD sequence has theoretical advantages for magnetic resonance imaging of structured materials such as tissue, where diffusion in compartmentalized and microstructured environments leads to fluctuating fields on a range of different time scales. We also show experimentally, both in excised tissue and in a live mouse tumor model, that optimal UDD sequences produce different T(2)-weighted contrast than do CPMG sequences with the same number of pulses and total delay, with substantial enhancements in most regions. This permits improved characterization of low-frequency spectral density functions in a wide range of applications.

dc.description.version

Version of Record

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/19947697

dc.identifier.eissn

1089-7690

dc.identifier.uri

https://hdl.handle.net/10161/3315

dc.language

eng

dc.language.iso

en_US

dc.publisher

AIP Publishing

dc.relation.ispartof

J Chem Phys

dc.relation.isversionof

10.1063/1.3263196

dc.relation.journal

Journal of Chemical Physics

dc.subject

Animals

dc.subject

Contrast Media

dc.subject

Health Care Reform

dc.subject

Magnetic Resonance Imaging

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Magnetic Resonance Spectroscopy

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Mice

dc.title

Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.

dc.type

Journal article

duke.contributor.orcid

Jenista, Elizabeth R|0000-0003-3140-7826

duke.date.pubdate

2009-11-28

duke.description.issue

20

duke.description.volume

131

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/19947697

pubs.begin-page

204510

pubs.issue

20

pubs.organisational-group

Chemistry

pubs.organisational-group

Duke

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Physics

pubs.organisational-group

School of Medicine

pubs.organisational-group

Staff

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.publication-status

Published

pubs.volume

131

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