Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.
dc.contributor.author | Berry, Mark F | |
dc.contributor.author | Coleman, Brooke K | |
dc.contributor.author | Curtis, Lesley H | |
dc.contributor.author | Worni, Mathias | |
dc.contributor.author | D'Amico, Thomas A | |
dc.contributor.author | Akushevich, Igor | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-06-05T19:48:07Z | |
dc.date.available | 2017-06-05T19:48:07Z | |
dc.date.issued | 2015-02 | |
dc.description.abstract | BACKGROUND: We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS: Factors associated with the use of adjuvant chemotherapy in patients older than 65 years of age who underwent surgical resection of T1-2N1M0 NSCLC without induction chemotherapy or radiation in the Surveillance, Epidemiology, and End Results-Medicare database from 1992 to 2006 were assessed using a multivariable logistic regression model that included treatment, patient, tumor, and census tract characteristics. Overall survival (OS) was analyzed using the Kaplan-Meier approach and inverse probability weight-adjusted Cox proportional hazard models. RESULTS: Overall, 2,781 patients who underwent surgical resection as the initial treatment for T1-2N1M0 NSCLC and survived at least 31 days after surgery were identified, with adjuvant chemotherapy given to 784 patients (28.2 %). Factors that predicted adjuvant chemotherapy use were younger age and higher T status. The 5-year OS was significantly better for patients who received adjuvant chemotherapy compared with patients not given adjuvant chemotherapy: 35.8 % (95 % confidence interval [CI] 31.9-39.6) vs. 28.0 % (95 % CI 25.9-30.0) (p = 0.008). In the inverse probability weight-adjusted Cox proportional hazard regression model, adjuvant chemotherapy use predicted significantly improved survival (hazard ratio 0.84; 95 % CI 0.76-0.92; p = 0.0002). CONCLUSIONS: Adjuvant chemotherapy after resection of T1-2N1M0 NSCLC is associated with significantly improved survival in patients older than 65 years. These data can be used to provide elderly patients with realistic expectations of the potential benefits when considering adjuvant chemotherapy in this setting. | |
dc.identifier | ||
dc.identifier.eissn | 1534-4681 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Ann Surg Oncol | |
dc.relation.isversionof | 10.1245/s10434-014-4056-0 | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Carcinoma, Non-Small-Cell Lung | |
dc.subject | Chemotherapy, Adjuvant | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Lung Neoplasms | |
dc.subject | Male | |
dc.subject | Neoplasm Staging | |
dc.subject | Pneumonectomy | |
dc.subject | Retrospective Studies | |
dc.subject | SEER Program | |
dc.subject | Survival Analysis | |
dc.title | Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients. | |
dc.type | Journal article | |
duke.contributor.orcid | Curtis, Lesley H|0000-0002-3286-9371 | |
pubs.author-url | ||
pubs.begin-page | 642 | |
pubs.end-page | 648 | |
pubs.issue | 2 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Duke Population Research Institute | |
pubs.organisational-group | Faculty | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, General Internal Medicine | |
pubs.organisational-group | Physics | |
pubs.organisational-group | Sanford School of Public Policy | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Social Science Research Institute | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
pubs.organisational-group | Trinity College of Arts & Sciences | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 22 |
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