Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.

Wang, Zongyao

Sundy, John S

Foss, Catherine M

Barnhart, Huiman X

Palmer, Scott M

Allgood, Sallie D

Trudeau, Evan

Alexander, Katie M

Levesque, Marc C

2020-07-01T15:37:59Z

2020-07-01T15:37:59Z

2013-01

2020-07-01T15:37:58Z

BACKGROUND: The CD14 C-159T single nucleotide polymorphism (SNP) has been investigated widely as a candidate genetic locus in patients with allergic disease. There are conflicting results for the association of the CD14 C-159T SNP with total serum immunoglobulin E (IgE) levels and atopy. There are limited data regarding the association of the CD14 C-159T SNP in subjects of African ancestry. The aim of the study was to determine whether the C-159T SNP and other CD14 SNPs (C1188G, C1341T) were associated with total serum IgE levels and with allergy skin test results in nonatopic and atopic subjects; as well as in Caucasian and African American subjects. METHODS: A total of 291 participants, 18-40 years old, were screened to determine whether they were atopic and/or asthmatic. Analyses were performed to determine the association between CD14 C-159T, C1188G, or C1341T genotypes with serum IgE levels and with the number of positive skin tests among Caucasian or African American subjects. RESULTS: We found no significant association of serum total IgE level with CD14 C-159T, C1188G, or C1341T genotypes within nonatopic or atopic subjects. Subjects with CD14-159 T alleles had significantly more positive allergen skin tests than subjects without CD14-159 T alleles (P = 0.0388). There was a significant association between the CD14 1188 G allele, but not the CD14 1341 T allele, with the number of positive skin-test results in Caucasians, but not in African Americans. CONCLUSION: These results support a possible association between CD14 polymorphisms and atopy. CD14-159 T or CD14 1188 G alleles were associated with atopic disease. For subjects with CD14 1188 G alleles, the association with atopic disease was stronger in Caucasians compared to African Americans.

jaa-6-081

1178-6965

1178-6965

https://hdl.handle.net/10161/21126

eng

Informa UK Limited

Journal of asthma and allergy

10.2147/jaa.s42695

CD14-159T

IgE

LPS

SNP

SPT

endotoxin

lipopolysaccharide

single nucleotide polymorphism

skin prick test

total serum immunoglobulin E

Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.

Journal article

Barnhart, Huiman X|0000-0003-0988-3439

Palmer, Scott M|0000-0002-1370-3771

Allgood, Sallie D|0000-0002-0329-4572

81

92

School of Medicine

Duke Clinical Research Institute

Medicine, Pulmonary, Allergy, and Critical Care Medicine

Duke

Institutes and Centers

Medicine

Clinical Science Departments

Biostatistics & Bioinformatics

Basic Science Departments

Immunology

Population Health Sciences

Duke Innovation & Entrepreneurship

Initiatives

Institutes and Provost's Academic Units

School of Nursing

Published

6