Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.

dc.contributor.author

Martin, John T

dc.contributor.author

Oldweiler, Alexander B

dc.contributor.author

Kosinski, Andrzej S

dc.contributor.author

Spritzer, Charles E

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Soher, Brian J

dc.contributor.author

Erickson, Melissa M

dc.contributor.author

Goode, Adam P

dc.contributor.author

DeFrate, Louis E

dc.date.accessioned

2024-08-14T15:57:25Z

dc.date.available

2024-08-14T15:57:25Z

dc.date.issued

2022-03

dc.description.abstract

Purpose

Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using standard clinical MRI. Our objective was to utilize our established MRI protocol for measuring disc function to quantify disc mechanical function in a healthy cohort.

Methods

We recruited young, asymptomatic volunteers (6 male/6 female; age 18-30 years; BMI < 30) and used MRI to determine how diurnal deformations in disc height, volume, and perimeter were affected by spinal level, disc region, MRI biomarkers of disc health (T2, T1rho), and Pfirrmann grade.

Results

Lumbar discs deformed by a mean of -6.1% (95% CI: -7.6%, -4.7%) to -8.0% (CI: -10.6%, -5.4%) in height and -5.4% (CI: -7.6%, -3.3%) to -8.5% (CI: -11.0%, -6.0%) in volume from AM to PM across spinal levels. Regional deformations were more uniform in cranial lumbar levels and concentrated posteriorly in the caudal levels, reaching a maximum of 13.1% at L5-S1 (CI:-16.1%, -10.2%). T2 and T1rho relaxation times were greatest in the nucleus and varied circumferentially within the annulus. T2 relaxation times were greatest at the most cranial spinal levels and decreased caudally. In this young healthy cohort, we identified a weak association between nucleus T2 and the diurnal change in the perimeter.

Conclusions

Spinal level is a key factor in determining regional disc deformations. Interestingly, deformations were concentrated in the posterior regions of caudal discs where disc herniation is most prevalent.
dc.identifier

10.1007/s00586-021-07097-4

dc.identifier.issn

0940-6719

dc.identifier.issn

1432-0932

dc.identifier.uri

https://hdl.handle.net/10161/31373

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

dc.relation.isversionof

10.1007/s00586-021-07097-4

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Lumbar Vertebrae

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Humans

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Low Back Pain

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Magnetic Resonance Imaging

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Adolescent

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Adult

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Female

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Male

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Young Adult

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Intervertebral Disc Displacement

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Intervertebral Disc

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Intervertebral Disc Degeneration

dc.title

Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.

dc.type

Journal article

duke.contributor.orcid

Kosinski, Andrzej S|0000-0003-4151-5185

duke.contributor.orcid

Goode, Adam P|0000-0002-0793-3298

duke.contributor.orcid

DeFrate, Louis E|0000-0002-6982-349X

pubs.begin-page

746

pubs.end-page

754

pubs.issue

3

pubs.organisational-group

Duke

pubs.organisational-group

Pratt School of Engineering

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School of Medicine

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Biostatistics & Bioinformatics

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Biomedical Engineering

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Orthopaedic Surgery

pubs.organisational-group

Radiology

pubs.organisational-group

Radiology, Musculoskeletal Imaging

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Duke Clinical Research Institute

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Duke-UNC Brain Imaging and Analysis Center

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Orthopaedic Surgery, Physical Therapy

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Neurosurgery

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Population Health Sciences

pubs.organisational-group

Duke Regeneration Center

pubs.organisational-group

Biostatistics & Bioinformatics, Division of Biostatistics

pubs.publication-status

Published

pubs.volume

31

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