Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.
dc.contributor.author | Yin, Ming | |
dc.contributor.author | Liao, Zhongxing | |
dc.contributor.author | Huang, Yu-Jing | |
dc.contributor.author | Liu, Zhensheng | |
dc.contributor.author | Yuan, Xianglin | |
dc.contributor.author | Gomez, Daniel | |
dc.contributor.author | Wang, Li-E | |
dc.contributor.author | Wei, Qingyi | |
dc.contributor.editor | Bernhard, Eric J | |
dc.date.accessioned | 2019-02-01T15:25:12Z | |
dc.date.available | 2019-02-01T15:25:12Z | |
dc.date.issued | 2011-01 | |
dc.date.updated | 2019-02-01T15:25:10Z | |
dc.description.abstract | The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic stability in response to irradiation. We hypothesized that genetic polymorphisms in DSB repair genes may affect clinical outcomes among non-small cell lung cancer (NSCLC) patients treated with definitive radio(chemo)therapy. We genotyped six potentially functional single nucleotide polymorphisms (SNPs) (i.e., RAD51 -135G>C/rs1801320 and -172G>T/rs1801321, XRCC2 4234G>C/rs3218384 and R188H/rs3218536 G>A, XRCC3 T241M/rs861539 and NBN E185Q/rs1805794) and estimated their associations with overall survival (OS) and radiation pneumonitis (RP) in 228 NSCLC patients. We found a predictive role of RAD51 -135G>C SNP in RP development (adjusted hazard ratio [HR] = 0.52, 95% confidence interval [CI], 0.31-0.86, P = 0.010 for CG/CC vs. GG). We also found that RAD51 -135G>C and XRCC2 R188H SNPs were independent prognostic factors for overall survival (adjusted HR = 1.70, 95% CI, 1.14-2.62, P = 0.009 for CG/CC vs. GG; and adjusted HR = 1.70; 95% CI, 1.02-2.85, P = 0.043 for AG vs. GG, respectively) and that the SNP-survival association was most pronounced in the presence of RP. Our study suggests that HR genetic polymorphisms, particularly RAD51 -135G>C, may influence overall survival and radiation pneumonitis in NSCLC patients treated with definitive radio(chemo)therapy. Large studies are needed to confirm our findings. | |
dc.identifier | PONE-D-11-01801 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.relation.ispartof | PloS one | |
dc.relation.isversionof | 10.1371/journal.pone.0020055 | |
dc.subject | Humans | |
dc.subject | Carcinoma, Non-Small-Cell Lung | |
dc.subject | Lung Neoplasms | |
dc.subject | Radiation Pneumonitis | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Treatment Outcome | |
dc.subject | Survival Analysis | |
dc.subject | Retrospective Studies | |
dc.subject | Recombination, Genetic | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.title | Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy. | |
dc.type | Journal article | |
duke.contributor.orcid | Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439 | |
pubs.begin-page | e20055 | |
pubs.issue | 5 | |
pubs.organisational-group | Staff | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Population Health Sciences | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Medicine, Medical Oncology | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.publication-status | Published | |
pubs.volume | 6 |
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