Intraindividual Comparison of Half-Dose Gadopiclenol and Standard-Dose Gadobenate Dimeglumine for Contrast-Enhanced Abdominal MRI.
Date
2026-01
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Attention Stats
Abstract
Background
Gadopiclenol is a high-relaxivity contrast agent enabling dose reduction while maintaining image quality. However, comparison with conventional agents remains limited in body MRI.Purpose
To intra-individually compare half-dose gadopiclenol and standard-dose gadobenate for image quality and lesion conspicuity in abdominal MRI.Study type
Retrospective.Population
One hundred patients (55 men; mean age: 64 ± 14 years) who underwent both abdominal MRI with gadobenate (0.1 mmol/kg) and gadopiclenol (0.05 mmol/kg) on the same scanner within 12 months.Field strength/sequence
1.5T/3T, dynamic T1-weighted imaging pre-contrast, early arterial (EAP), late arterial (LAP), portal venous (PVP), and equilibrium phases (EP) using 3D fat-suppressed gradient echo sequence.Assessment
Signal intensity of liver, pancreas, spleen, kidneys, aorta, portal vein, and abdominal lesions was measured on each phase except EAP. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and magnitude of contrast enhancement (ΔE) were calculated for organs. In lesions, lesion-to-background ratio (LBR) and ΔE were calculated. Subjective image quality and lesion conspicuity were assessed by three readers using a 5-point Likert scale.Statistical tests
Paired t-test and Wilcoxon test. p < 0.05 indicated statistically significant results.Results
Gadopiclenol yielded significantly higher CNR and SNR for pancreas, portal vein, and kidney in LAP. No significant differences in CNR (p: 0.372-0.858) and SNR (p: 0.433-0.936) were found in PVP. In EP, gadobenate showed higher hepatic CNR, while CNR and SNR of all other organs were comparable (p: 0.103-0.912). Gadopiclenol showed higher pancreatic ΔE in all enhanced phases. LBR and ΔE of 21 evaluated lesions were comparable across all phases (p: 0.100-0.821). No significant differences were observed in readers' perception of lesion enhancement (p: 0.059-0.957).Conclusion
Half-dose gadopiclenol provides comparable subjective image quality and lesion conspicuity to standard-dose gadobenate, with superior pancreatic, kidney, and portal vein enhancement in LAP, and similar performance in PVP and EP.Level of evidence: 4
Type
Department
Description
Provenance
Subjects
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Del Gaudio, Antonella, Domenico De Santis, Ludovica Lofino, Danielle E Kruse, Kevin R Kalisz, Rajan T Gupta, Francesco Ria, Daniele Marin, et al. (2026). Intraindividual Comparison of Half-Dose Gadopiclenol and Standard-Dose Gadobenate Dimeglumine for Contrast-Enhanced Abdominal MRI. Journal of magnetic resonance imaging : JMRI. 10.1002/jmri.70207 Retrieved from https://hdl.handle.net/10161/34190.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
Danielle Elizabeth Kruse
Kevin Ryan Kalisz
Rajan Tilak Gupta
Abdominal Imaging; Multiparametric MR imaging of prostate cancer; MR imaging of the hepatobiliary system; Applications of dual energy CT in the abdomen and pelvis
Francesco Ria
Dr. Francesco Ria is a medical physicist and he serves as an Assistant Professor in the Department of Radiology. Francesco has an extensive expertise in the assessment of procedure performances in radiology. In particular, his research activities focus on the simultaneous evaluation of radiation dose and image quality in vivo in computed tomography providing a comprehensive evaluation of radiological exams. Moreover, Francesco is developing and investigating novel mathematical models that, uniquely in the radiology field, can incorporate a comprehensive and quantitative risk-to-benefit assessment of the procedures; he is continuing to apply his expertise towards the definition of new patient specific risk metrics, and in the assessment of image quality in vivo also using state-of-the-art imaging technology, such as photon counting computed tomography scanners, and machine learning reconstruction algorithms.
Dr. Ria is a member of the American Association of Physicists in Medicine (AAPM) task group 392 (Investigation and Quality Control of Automatic Exposure Control System in CT), of the AAPM task group 430 (Comprehensive quantification and dissemination of patient-model-based organ and effective dose estimations and their associated uncertainties for CT examinations), of the AAPM Medicine Public Education working group (WGATE), and of the Italian Association of Medical Physics task group Dose Monitoring in Diagnostic Imaging.
Daniele Marin
Liver Imaging
Dual Energy CT
CT Protocol Optimization
Dose Reduction Strategies for Abdominal CT Applications
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.