Amiodarone-Induced Liver Injury and Cirrhosis.
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2015-01
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We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.
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Buggey, Jonathan, Matthew Kappus, Anand S Lagoo and Carla W Brady (2015). Amiodarone-Induced Liver Injury and Cirrhosis. ACG Case Rep J, 2(2). pp. 116–118. 10.14309/crj.2015.23 Retrieved from https://hdl.handle.net/10161/10886.
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Scholars@Duke
Matthew Robert Kappus
Anand Shreeram Lagoo
My clinical interests are focused on diagnosis of hematological malignancies (leukemia, lymphoma, Hodgkin disease, multiple myeloma, etc). I devote majority of my effort to provide diagnostic interpretation based on morphological examination of blood, bone marrow, lymph node, other lymphoid organs like spleen, as well as any other organ and tissue suspected to harbor lymphoma or leukemia. The morphological findings are integrated with results of ancillary studies including flow cytometry, cytogenetics and molecular diagnostics, as well as key clinical, radiographic, and laboratory findings.
As medical director of the Clinical Flow Cytometry laboratory, I oversee the operations of the lab to ensure accuracy and timely delivery of these high complexity diagnostic tests. Development and validation of flow cytometric tests to provide prognostic information and evaluation of therapeutic targets to guide treatment is also an important aspect of my work.
My translational research interests include-
1. Correlation of flow cytometric, cytogenetic and molecular findings in acute myeloid leukemias with myelodysplasia associated changes and in acute leukemias with monocytic differentiation.
2. Morphological changes following non-conventional treatments for myeloid, lymphoid, and plasma cell neoplasms.
3. The spectrum of lymphoid tissue involvement by plasmacytic / plasmacytoid cells.
Carla Wheaton Brady
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