Antifungal drugs: Special problems treating central nervous system infections

dc.contributor.author

Ashley, ED

dc.date.accessioned

2019-12-07T15:30:24Z

dc.date.available

2019-12-07T15:30:24Z

dc.date.issued

2019-12-01

dc.date.updated

2019-12-07T15:30:23Z

dc.description.abstract

© 2019 by the author. Licensee MDPI, Basel, Switzerland. Treating fungal infections in the central nervous system (CNS) remains a challenge despite the availability of new antifungal agents. Therapy is limited by poor understanding of the kinetic properties of antifungal drugs in the CNS compounded by lack of data for many agents. In some cases, clinical response rates do not correspond to data on drug concentrations in the cerebral spinal fluid and/or brain parenchyma. In order to better characterize the use of antifungal agents in treating CNS infections, a review of the essential principles of neuroPK are reviewed. Specific data regarding antifungal drug concentrations in the cerebral spinal fluid and brain tissue are described from human data where available. Alternative dosing regimens and the role of antifungal drug concentration monitoring in treating fungal infections in the CNS are also discussed. Having a better understanding of these key concepts will help guide clinicians in determining the best treatment courses for patients with these devastating infections.

dc.identifier.issn

2309-608X

dc.identifier.uri

https://hdl.handle.net/10161/19569

dc.language

en

dc.publisher

MDPI AG

dc.relation.ispartof

Journal of Fungi

dc.relation.isversionof

10.3390/jof5040097

dc.title

Antifungal drugs: Special problems treating central nervous system infections

dc.type

Journal article

pubs.begin-page

97

pubs.end-page

97

pubs.issue

4

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke

pubs.organisational-group

Medicine, Infectious Diseases

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

5

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