Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.
dc.contributor.author | Thongprayoon, Charat | |
dc.contributor.author | Kaewput, Wisit | |
dc.contributor.author | Boonpheng, Boonphiphop | |
dc.contributor.author | Ungprasert, Patompong | |
dc.contributor.author | Bathini, Tarun | |
dc.contributor.author | Srivali, Narat | |
dc.contributor.author | Vallabhajosyula, Saraschandra | |
dc.contributor.author | Castaneda, Jorge L | |
dc.contributor.author | Monga, Divya | |
dc.contributor.author | Kanduri, Swetha R | |
dc.contributor.author | Medaura, Juan | |
dc.contributor.author | Cheungpasitporn, Wisit | |
dc.date.accessioned | 2023-10-11T19:47:08Z | |
dc.date.available | 2023-10-11T19:47:08Z | |
dc.date.issued | 2020-03 | |
dc.date.updated | 2023-10-11T19:47:07Z | |
dc.description.abstract | Background and objectives: Goodpasture's syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture's syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone. | |
dc.identifier | medicina56030103 | |
dc.identifier.issn | 1010-660X | |
dc.identifier.issn | 1648-9144 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | MDPI AG | |
dc.relation.ispartof | Medicina (Kaunas, Lithuania) | |
dc.relation.isversionof | 10.3390/medicina56030103 | |
dc.subject | Humans | |
dc.subject | Anti-Glomerular Basement Membrane Disease | |
dc.subject | Hospitalization | |
dc.subject | Hospital Mortality | |
dc.subject | Databases, Factual | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Inpatients | |
dc.subject | Patient Acceptance of Health Care | |
dc.subject | United States | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | |
dc.title | Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014. | |
dc.type | Journal article | |
duke.contributor.orcid | Srivali, Narat|0000-0002-6945-329X | |
pubs.begin-page | E103 | |
pubs.issue | 3 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Pulmonary, Allergy, and Critical Care Medicine | |
pubs.publication-status | Published | |
pubs.volume | 56 |
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