Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.

dc.contributor.author

Thongprayoon, Charat

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Kaewput, Wisit

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Boonpheng, Boonphiphop

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Ungprasert, Patompong

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Bathini, Tarun

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Srivali, Narat

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Vallabhajosyula, Saraschandra

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Castaneda, Jorge L

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Monga, Divya

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Kanduri, Swetha R

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Medaura, Juan

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Cheungpasitporn, Wisit

dc.date.accessioned

2023-10-11T19:47:08Z

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2023-10-11T19:47:08Z

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2020-03

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2023-10-11T19:47:07Z

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Background and objectives: Goodpasture's syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture's syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods: We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results: A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions: Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone.

dc.identifier

medicina56030103

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1010-660X

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1648-9144

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https://hdl.handle.net/10161/29260

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eng

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MDPI AG

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Medicina (Kaunas, Lithuania)

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10.3390/medicina56030103

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Humans

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Anti-Glomerular Basement Membrane Disease

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Hospitalization

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Hospital Mortality

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Databases, Factual

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Adult

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Aged

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Middle Aged

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Inpatients

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Patient Acceptance of Health Care

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United States

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Female

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Male

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

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Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.

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Journal article

duke.contributor.orcid

Srivali, Narat|0000-0002-6945-329X

pubs.begin-page

E103

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3

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Duke

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School of Medicine

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Clinical Science Departments

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Medicine

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Medicine, Pulmonary, Allergy, and Critical Care Medicine

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Published

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56

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