Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.

Brummett, Beverly H

Babyak, Michael A

Singh, Abanish

Hauser, Elizabeth R

Jiang, Rong

Huffman, Kim M

Kraus, William E

Shah, Svati H

Siegler, Ilene C

Williams, Redford B

2023-03-28T14:13:19Z

2023-03-28T14:13:19Z

2018-01

2023-03-28T14:13:17Z

The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C gene, Cys23Ser (rs6318), has been associated with depressive symptoms. and adiposity; however, these findings have been inconsistent. The reasons for this mixed picture may be due to low statistical power or due to other factors such as failure to account for possible interacting environmental factors, such as psychosocial stress. Further, the literature around this polymorphism is marked by limited inclusion of persons of African ancestry. The present study sought to overcome these limitations and definitively determine the relationship of this polymorphism with depressive and obesity phenotypes in a large sample meta-analysis. Thus, we harmonized individual level data from 10 studies including the Women's Health Initiative, CARDIA, ARIC, Framingham Offspring, and the Jackson Heart Study, resulting in a sample of 27,161 individuals (10,457 Black women, 2,819 Black men, 7,419 White women, and 6,466 White men). We conducted a random effects meta-analysis using individual level data to examine whether the Cys23Ser variant-either directly, or conditionally depending on the level of psychosocial stress-was associated with depressive symptoms and body mass index (BMI). We found that psychosocial stress was associated with both depression and BMI, but that Cys23Ser was not directly associated with, nor did it modify the associations of psychosocial stress with depression or BMI. Thus, in the largest study of this polymorphism, we have determined that rs6318 is not associated with depression, or BMI.

1664-8021

1664-8021

https://hdl.handle.net/10161/26765

eng

Frontiers Media SA

Frontiers in genetics

10.3389/fgene.2018.00423

body mass index

depressive symptoms

race

rs6318

sex

stress

Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.

Journal article

Hauser, Elizabeth R|0000-0003-0367-9189

Kraus, William E|0000-0003-1930-9684

Shah, Svati H|0000-0002-3495-2830

Williams, Redford B|0000-0002-8581-0648

423

OCT

Duke

School of Medicine

School of Nursing

Trinity College of Arts & Sciences

Nursing

Basic Science Departments

Clinical Science Departments

Institutes and Centers

Biostatistics & Bioinformatics

Medicine

Psychiatry & Behavioral Sciences

Medicine, Cardiology

Medicine, Rheumatology and Immunology

Duke Cancer Institute

Psychology & Neuroscience

Duke Clinical Research Institute

Duke Molecular Physiology Institute

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

Regeneration Next Initiative

Published

9