Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.

dc.contributor.author

Simhal, Anish K

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Carpenter, Kimberly LH

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Nadeem, Saad

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Kurtzberg, Joanne

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Song, Allen

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Tannenbaum, Allen

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Sapiro, Guillermo

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Dawson, Geraldine

dc.date.accessioned

2022-03-23T15:07:41Z

dc.date.available

2022-03-23T15:07:41Z

dc.date.issued

2020-07-02

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2022-03-23T15:07:40Z

dc.description.abstract

Ollivier-Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). In an open label clinical trials, participants with ASD were administered a single infusion of autologous umbilical cord blood and, as part of their clinical outcome measures, were imaged with diffusion MRI before and after the infusion. By using Ricci curvature to measure changes in robustness, we quantified both local and global changes in the brain networks and their potential relationship with the infusion. Our results find changes in the curvature of the connections between regions associated with ASD that were not detected via traditional brain network analysis.

dc.identifier

10.1038/s41598-020-67474-9

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2045-2322

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2045-2322

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https://hdl.handle.net/10161/24572

dc.language

eng

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Springer Science and Business Media LLC

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Scientific reports

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10.1038/s41598-020-67474-9

dc.subject

Nerve Net

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Fetal Blood

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Humans

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Diffusion Magnetic Resonance Imaging

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Blood Transfusion, Autologous

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Child, Preschool

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Female

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Male

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White Matter

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Autism Spectrum Disorder

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Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.

dc.type

Journal article

duke.contributor.orcid

Carpenter, Kimberly LH|0000-0002-3838-798X

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Kurtzberg, Joanne|0000-0002-3370-0703

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Dawson, Geraldine|0000-0003-1410-2764

pubs.begin-page

10819

pubs.issue

1

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Duke

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Pratt School of Engineering

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Sanford School of Public Policy

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School of Medicine

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Trinity College of Arts & Sciences

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Sanford

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Neurobiology

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Biomedical Engineering

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Electrical and Computer Engineering

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Pathology

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Pediatrics

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Radiology

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Duke Cancer Institute

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Computer Science

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Global Health Institute

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Duke Institute for Brain Sciences

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Initiatives

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Duke Innovation & Entrepreneurship

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Pediatrics, Transplant and Cellular Therapy

pubs.publication-status

Published

pubs.volume

10

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