Characterization of the standard and recommended CODIS markers.

dc.contributor.author

Katsanis, Sara H

dc.contributor.author

Wagner, Jennifer K

dc.date.accessioned

2018-10-05T15:44:13Z

dc.date.available

2018-10-05T15:44:13Z

dc.date.issued

2013-01

dc.date.updated

2018-10-05T15:44:13Z

dc.description.abstract

As U.S. courts grapple with constitutional challenges to DNA identification applications, judges are resting legal decisions on the fingerprint analogy, questioning whether the information from a DNA profile could, in light of scientific advances, reveal biomedically relevant information. While CODIS loci were selected largely because they lack phenotypic associations, how this criterion was assessed is unclear. To clarify their phenotypic relevance, we describe the standard and recommended CODIS markers within the context of what is known currently about the genome. We characterize the genomic regions and phenotypic associations of the 24 standard and suggested CODIS markers. None of the markers are within exons, although 12 are intragenic. No CODIS genotypes are associated with known phenotypes. This study provides clarification of the genomic significance of the key identification markers and supports--independent of the forensic scientific community--that the CODIS profiles provide identification but not sensitive or biomedically relevant information.

dc.identifier.issn

0022-1198

dc.identifier.issn

1556-4029

dc.identifier.uri

https://hdl.handle.net/10161/17572

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

Journal of forensic sciences

dc.relation.isversionof

10.1111/j.1556-4029.2012.02253.x

dc.subject

Humans

dc.subject

Genetic Markers

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DNA Fingerprinting

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Microsatellite Repeats

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Genotype

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Phenotype

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Mutation

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Polymorphism, Single Nucleotide

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Introns

dc.subject

Databases, Genetic

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Forensic Genetics

dc.subject

Genetic Loci

dc.title

Characterization of the standard and recommended CODIS markers.

dc.type

Journal article

duke.contributor.orcid

Katsanis, Sara H|0000-0002-5044-8765

pubs.begin-page

S169

pubs.end-page

S172

pubs.issue

SUPPL. 1

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

Duke

pubs.organisational-group

Duke Science & Society

pubs.organisational-group

Initiatives

pubs.publication-status

Published

pubs.volume

58 Suppl 1

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