Early Mesozoic Coexistence of Amniotes and Hepadnaviridae

Loading...
Thumbnail Image

Date

2014-12-11

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

285
views
236
downloads

Citation Stats

Attention Stats

Abstract

Author Summary

Viruses are not known to leave physical fossil traces, which makes our understanding of their evolutionary prehistory crucially dependent on the detection of endogenous viruses. Ancient endogenous viruses, also known as paleoviruses, are relics of viral genomes or fragments thereof that once infiltrated their host's germline and then remained as molecular “fossils” within the host genome. The massive genome sequencing of recent years has unearthed vast numbers of paleoviruses from various animal genomes, including the first endogenous hepatitis B viruses (eHBVs) in bird genomes. We screened genomes of land vertebrates (amniotes) for the presence of paleoviruses and identified ancient eHBVs in the recently sequenced genomes of crocodilians, snakes, and turtles. We report an eHBV that is >207 million years old, making it the oldest endogenous virus currently known. Furthermore, our results provide direct evidence that the Hepadnaviridae virus family infected birds, crocodilians and turtles during the Mesozoic Era, and suggest a long-lasting coexistence of these viruses and their amniote hosts at least since the Early Mesozoic. We challenge previous views on the origin of the oncogenic X gene and provide an evolutionary explanation as to why only mammalian hepatitis B infection leads to hepatocellular carcinoma.

Department

Description

Provenance

Subjects

Citation

Published Version (Please cite this version)

10.1371/journal.pgen.1004559

Publication Info

Suh, A, CC Weber, C Kehlmaier, EL Braun, RE Green, U Fritz, DA Ray, H Ellegren, et al. (2014). Early Mesozoic Coexistence of Amniotes and Hepadnaviridae. PLoS Genet, 10(12). p. e1004559. 10.1371/journal.pgen.1004559 Retrieved from https://hdl.handle.net/10161/9326.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.