Low-density lipoprotein cholesterol and survival in pulmonary arterial hypertension.

dc.contributor.author

Kopeć, Grzegorz

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Waligóra, Marcin

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Tyrka, Anna

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Jonas, Kamil

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Pencina, Michael J

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Zdrojewski, Tomasz

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Moertl, Deddo

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Stokwiszewski, Jakub

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Zagożdżon, Paweł

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Podolec, Piotr

dc.date.accessioned

2020-05-06T17:56:40Z

dc.date.available

2020-05-06T17:56:40Z

dc.date.issued

2017-02-15

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2020-05-06T17:56:39Z

dc.description.abstract

Low-density lipoprotein cholesterol(LDL-C) is a well established metabolic marker of cardiovascular risk, however, its role in pulmonary arterial hypertension (PAH) has not been determined. Therefore we assessed whether LDL-C levels are altered in PAH patients, if they are associated with survival in this group and whether pulmonary hypertension (PH) reversal can influence LDL-C levels. Consecutive 46 PAH males and 94 females were age matched with a representative sample of 1168 males and 1245 females, respectively. Cox regression models were used to assess the association between LDL-C and mortality. The effect of PH reversal on LDL-C levels was assessed in 34 patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing invasive treatment. LDL-C was lower in both PAH (2.6 ± 0.8 mmol/l) and CTEPH (2.7 ± 0.7 mmol/l) patients when compared to controls (3.2 ± 1.1 mmol/l, p < 0.001). In PAH patients lower LDL-C significantly predicted death (HR:0.44/1 mmol/l, 95%CI:0.26-0.74, p = 0.002) after a median follow-up time of 33(21-36) months. In the CTEPH group, LDL-C increased (from 2.6[2.1-3.2] to 4.0[2.8-4.9]mmol/l, p = 0.01) in patients with PH reversal but remained unchanged in other patients (2.4[2.2-2.7] vs 2.3[2.1-2.5]mmol/l, p = 0.51). We concluded that LDL-C level is low in patients with PAH and is associated with an increased risk of death. Reversal of PH increases LDL-C levels.

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srep41650

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2045-2322

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2045-2322

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https://hdl.handle.net/10161/20620

dc.language

eng

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Springer Science and Business Media LLC

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Scientific reports

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10.1038/srep41650

dc.subject

Humans

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Hypertension, Pulmonary

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Prognosis

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Proportional Hazards Models

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Risk Factors

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Case-Control Studies

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Follow-Up Studies

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Age Factors

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Sex Factors

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Adult

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Middle Aged

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Female

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Male

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Cholesterol, LDL

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Biomarkers

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Low-density lipoprotein cholesterol and survival in pulmonary arterial hypertension.

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Journal article

duke.contributor.orcid

Pencina, Michael J|0000-0001-5798-8855|0000-0002-1968-2641

pubs.begin-page

41650

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1

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School of Medicine

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Duke Clinical Research Institute

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Biostatistics & Bioinformatics

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Duke

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Institutes and Centers

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Basic Science Departments

pubs.publication-status

Published

pubs.volume

7

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