Inner ear delivery: Challenges and opportunities.

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Date

2020-02

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Abstract

Objectives

The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation.

Data sources

The databases used were PubMed, EMBASE, and Web of Science.

Results

Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants.

Conclusions

In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation.

Level of evidence

NA.

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Published Version (Please cite this version)

10.1002/lio2.336

Publication Info

Szeto, Betsy, Harry Chiang, Chris Valentini, Michelle Yu, Jeffrey W Kysar and Anil K Lalwani (2020). Inner ear delivery: Challenges and opportunities. Laryngoscope investigative otolaryngology, 5(1). pp. 122–131. 10.1002/lio2.336 Retrieved from https://hdl.handle.net/10161/28256.

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