Mapping SARS-CoV-2 antigenic relationships and serological responses.

Abstract

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)-1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.

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Published Version (Please cite this version)

10.1126/science.adj0070

Publication Info

Wilks, Samuel H, Barbara Mühlemann, Xiaoying Shen, Sina Türeli, Eric B LeGresley, Antonia Netzl, Miguela A Caniza, Jesus N Chacaltana-Huarcaya, et al. (2023). Mapping SARS-CoV-2 antigenic relationships and serological responses. Science (New York, N.Y.), 382(6666). p. eadj0070. 10.1126/science.adj0070 Retrieved from https://hdl.handle.net/10161/29318.

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