Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.

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2010-09-17

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Abstract

A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.

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10.1021/ol101863s

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Zhang, Jiming, Sheng Li, Dehui Zhang, Hua Wang, A Richard Whorton and Ming Xian (2010). Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. Org Lett, 12(18). pp. 4208–4211. 10.1021/ol101863s Retrieved from https://hdl.handle.net/10161/4108.

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