Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
| dc.contributor.author | Zhang, Jiming | |
| dc.contributor.author | Li, Sheng | |
| dc.contributor.author | Zhang, Dehui | |
| dc.contributor.author | Wang, Hua | |
| dc.contributor.author | Whorton, A Richard | |
| dc.contributor.author | Xian, Ming | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2011-06-21T17:27:11Z | |
| dc.date.issued | 2010-09-17 | |
| dc.description.abstract | A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins. | |
| dc.description.version | Version of Record | |
| dc.identifier | ||
| dc.identifier.eissn | 1523-7052 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | |
| dc.relation.ispartof | Org Lett | |
| dc.relation.isversionof | 10.1021/ol101863s | |
| dc.relation.journal | Organic letters | |
| dc.subject | Disulfides | |
| dc.subject | Molecular Structure | |
| dc.subject | Oxidation-Reduction | |
| dc.subject | Phosphines | |
| dc.subject | S-Nitrosothiols | |
| dc.title | Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. | |
| dc.title.alternative | ||
| dc.type | Journal article | |
| duke.date.pubdate | 2010-9-17 | |
| duke.description.issue | 18 | |
| duke.description.volume | 12 | |
| pubs.author-url | ||
| pubs.begin-page | 4208 | |
| pubs.end-page | 4211 | |
| pubs.issue | 18 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Faculty | |
| pubs.publication-status | Published | |
| pubs.volume | 12 |