The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration.

Logue, Mark W

Amstadter, Ananda B

Baker, Dewleen G

Duncan, Laramie

Koenen, Karestan C

Liberzon, Israel

Miller, Mark W

Morey, Rajendra A

Nievergelt, Caroline M

Ressler, Kerry J

Smith, Alicia K

Smoller, Jordan W

Stein, Murray B

Sumner, Jennifer A

Uddin, Monica

England

2015-12-03T15:02:40Z

2015-09

The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Psychiatric genetics has moved beyond examination of specific candidate genes in favor of the genome-wide association study (GWAS) strategy of very large numbers of samples, which allows for the discovery of previously unsuspected genes and molecular pathways. The successes of genetic studies of schizophrenia and bipolar disorder have been aided by the formation of a large-scale GWAS consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the contingency on trauma exposure and the large degree of ancestral genetic diversity within and across participating studies. Using the PGC analysis pipeline supplemented by analyses tailored to address these challenges, we anticipate that our first large-scale GWAS of PTSD will comprise over 10 000 cases and 30 000 trauma-exposed controls. Following in the footsteps of our PGC forerunners, this collaboration-of a scope that is unprecedented in the field of traumatic stress-will lead the search for replicable genetic associations and new insights into the biological underpinnings of PTSD.

http://www.ncbi.nlm.nih.gov/pubmed/25904361

npp2015118

1740-634X

https://hdl.handle.net/10161/10965

eng

Springer Science and Business Media LLC

Neuropsychopharmacology

10.1038/npp.2015.118

Cooperative Behavior

Genetic Predisposition to Disease

Genome-Wide Association Study

Genomics

Humans

Psychiatric Status Rating Scales

Stress Disorders, Post-Traumatic

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/25904361

2287

2297

10

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke-UNC Center for Brain Imaging and Analysis

Institutes and Centers

Institutes and Provost's Academic Units

Psychiatry & Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience

School of Medicine

University Institutes and Centers

Published

40