Cell and extracellular matrix growth theory and its implications for tumorigenesis.

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2021-03

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Abstract

Cells associated with an abnormal (cancerous) growth exchange flows, morph freely and grow hand-in-glove with their immediate environment, the extracellular matrix (ECM). The cell structure experiences two mass flows in counterflow. Flowing into the structure are nutrients and flowing out is refuse from the metabolically active biomass within. The physical effect of the evolution of the cell and extracellular structure is more flow and mixing in that space, that is, more mixing than in the absence of a biological growth in that space. The objective of the present theory is to predict the increase in the size of the cell cluster as a function of its structure, and also to predict the critical cluster sizes that mark the transitions from one distinct cluster configuration to the next. This amounts to predicting the timing and the main features of the transitions from single cell to clusters with two, four, eight and more cells, including larger clusters with cells organized on its outer surface. The predicted evolution of the size and configuration of the cell cluster is validated successfully by comparison with measurements from several independent studies of cancerous and non-cancerous growth patterns.

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10.1016/j.biosystems.2020.104331

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Sauer, TJ, E Samei and A Bejan (2021). Cell and extracellular matrix growth theory and its implications for tumorigenesis. Bio Systems, 201. p. 104331. 10.1016/j.biosystems.2020.104331 Retrieved from https://hdl.handle.net/10161/22453.

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Bejan

Adrian Bejan

J.A. Jones Distinguished Professor of Mechanical Engineering

Professor Bejan was awarded the Benjamin Franklin Medal 2018 and the Humboldt Research Award 2019. His research covers engineering science and applied physics: thermodynamics, heat transfer, convection, design, and evolution in nature.

He is ranked among the top 0.01% of the most cited and impactful world scientists (and top 10 in Engineering world wide) in the 2019 citations impact database created by Stanford University’s John Ioannidis, in PLoS Biology.  He is the author of 30 books and 700 peer-referred articles. His h-index is 111 with 92,000 citations on Google Scholar. He received 18 honorary doctorates from universities in 11 countries.


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