Brucellosis among hospitalized febrile patients in northern Tanzania.
dc.contributor.author | Bouley, Andrew J | |
dc.contributor.author | Biggs, Holly M | |
dc.contributor.author | Stoddard, Robyn A | |
dc.contributor.author | Morrissey, Anne B | |
dc.contributor.author | Bartlett, John A | |
dc.contributor.author | Afwamba, Isaac A | |
dc.contributor.author | Maro, Venance P | |
dc.contributor.author | Kinabo, Grace D | |
dc.contributor.author | Saganda, Wilbrod | |
dc.contributor.author | Cleaveland, Sarah | |
dc.contributor.author | Crump, John A | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2017-03-02T19:23:18Z | |
dc.date.available | 2017-03-02T19:23:18Z | |
dc.date.issued | 2012-12 | |
dc.description.abstract | Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a ≥ 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer ≥ 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with ≥ 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania. | |
dc.identifier | ||
dc.identifier | ajtmh.2012.12-0327 | |
dc.identifier.eissn | 1476-1645 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | American Society of Tropical Medicine and Hygiene | |
dc.relation.ispartof | Am J Trop Med Hyg | |
dc.relation.isversionof | 10.4269/ajtmh.2012.12-0327 | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Animals | |
dc.subject | Brucellosis | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Female | |
dc.subject | Fever | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Inpatients | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Odds Ratio | |
dc.subject | Prevalence | |
dc.subject | Risk Factors | |
dc.subject | Tanzania | |
dc.subject | Young Adult | |
dc.title | Brucellosis among hospitalized febrile patients in northern Tanzania. | |
dc.type | Journal article | |
duke.contributor.orcid | Crump, John A|0000-0002-4529-102X | |
pubs.author-url | ||
pubs.begin-page | 1105 | |
pubs.end-page | 1111 | |
pubs.issue | 6 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Science & Society | |
pubs.organisational-group | Global Health Institute | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | School of Nursing | |
pubs.organisational-group | School of Nursing - Secondary Group | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 87 |
Files
Original bundle
- Name:
- AmJTropMedHyg_Brucellosis.pdf
- Size:
- 469.57 KB
- Format:
- Adobe Portable Document Format