Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal.

Moore, John W

United States

2016-01-16T20:48:09Z

2015-10-06

The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus time showed that raising the HH variable n to the sixth power provided the best fit to the data. Subsequent simulations using n(6) and setting the resting potential at the in vivo value simplifies the HH equations by eliminating the leakage term. Our article also reported that the K current in response to a depolarizing step to ENa was delayed if the step was preceded by a hyperpolarization. While the interpretation of this phenomenon in the article was flawed, subsequent simulations show that the effect completely arises from the original HH equations.

http://www.ncbi.nlm.nih.gov/pubmed/26445431

S0006-3495(15)00818-8

1542-0086

https://hdl.handle.net/10161/11524

eng

Elsevier BV

Biophys J

10.1016/j.bpj.2015.08.008

Animals

Axons

Biophysics

Computer Simulation

Decapodiformes

History, 20th Century

Membrane Potentials

Models, Neurological

Potassium

Potassium Channels

Sodium

Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/26445431

1317

1320

7

Basic Science Departments

Duke

Neurobiology

School of Medicine

Published

109