Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.

dc.contributor.author

Levine, Amber T

dc.contributor.author

Born, Heather A

dc.contributor.author

Landstrom, Andrew P

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Larson, Samuel

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Lee, Wai Ling

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Dao, An T

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Wehrens, Xander H

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Lai, Yi-Chen

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Anderson, Anne E

dc.date.accessioned

2020-04-01T13:22:32Z

dc.date.available

2020-04-01T13:22:32Z

dc.date.issued

2020-03-04

dc.date.updated

2020-04-01T13:22:29Z

dc.description.abstract

Status epilepticus (SE) is a prevalent disorder associated with significant morbidity, including the development of epilepsy and mortality. Cardiac arrhythmias (i.e. inappropriate sinus tachycardia and bradycardia, asystole, and atrioventricular blocks) are observed in patients following SE. We characterized ictal (during a seizure) and interictal (between seizure) cardiac arrhythmogenesis following SE using continuous electrocardiography and video electroencephalography (vEEG) recordings throughout a 14-day monitoring period in an intrahippocampal chemoconvulsant mouse model that develops epilepsy. We quantified heart rhythm abnormalities and examined whether the frequency of cardiac events correlated with epileptiform activity, circadian (light/dark) cycle, the presence of seizures, and survival during this period of early epileptogenesis (the development of epilepsy) following SE. Shortly following SE, mice developed an increased interictal heart rate and heart rhythm abnormalities (i.e. sinus pause and sinus arrhythmias) when compared to control mice. Heart rhythm abnormalities were more frequent during the light cycle and were not correlated with increased epileptiform activity or seizure frequency. Finally, SE animals had early mortality, and a death event captured during vEEG recording demonstrated severe bradycardia prior to death. These cardiac changes occurred within 14 days after SE and may represent an early risk factor for sudden death following SE.

dc.identifier

10.1038/s41598-020-60324-8

dc.identifier.issn

2045-2322

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2045-2322

dc.identifier.uri

https://hdl.handle.net/10161/20287

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Scientific reports

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10.1038/s41598-020-60324-8

dc.title

Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.

dc.type

Journal article

duke.contributor.orcid

Landstrom, Andrew P|0000-0002-1878-9631

pubs.begin-page

4043

pubs.issue

1

pubs.organisational-group

School of Medicine

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Cell Biology

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Pediatrics, Cardiology

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Duke

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Basic Science Departments

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Pediatrics

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Clinical Science Departments

pubs.publication-status

Published

pubs.volume

10

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