Caspases: an ancient cellular sword of Damocles.

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2004-01

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Abstract

Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.

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10.1038/sj.cdd.4401339

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Boyce, M, A Degterev and J Yuan (2004). Caspases: an ancient cellular sword of Damocles. Cell death and differentiation, 11(1). pp. 29–37. 10.1038/sj.cdd.4401339 Retrieved from https://hdl.handle.net/10161/19708.

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Boyce

Michael Scott Boyce

Associate Professor of Biochemistry

The Boyce Lab studies mammalian cell signaling through protein glycosylation. For the latest news, project information and publications from our group, please visit our web site at http://www.boycelab.org or follow us on Twitter at https://twitter.com/BoyceLab.


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