An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector
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2020-11-16
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<jats:p> <jats:named-content content-type="genus-species">Borrelia burgdorferi</jats:named-content> causes Lyme disease, the most common tick-transmitted illness in North America. When <jats:named-content content-type="genus-species">Ixodes scapularis</jats:named-content> feed on an infected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vector. Here, we show that a secreted tick protein, <jats:named-content content-type="genus-species"> <jats:underline>I</jats:underline> . <jats:underline>s</jats:underline> capularis </jats:named-content> <jats:underline>p</jats:underline> rotein <jats:underline>d</jats:underline> isulfide <jats:underline>i</jats:underline> somerase <jats:underline>A3</jats:underline> (IsPDIA3), enhances <jats:named-content content-type="genus-species">B. burgdorferi</jats:named-content> colonization of the tick gut. </jats:p>
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Cao, Yongguo, Connor Rosen, Gunjan Arora, Akash Gupta, Carmen J Booth, Kristen E Murfin, Jiri Cerny, Alejandro Marin Lopez, et al. (2020). An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector. Infection and Immunity, 88(12). 10.1128/iai.00426-20 Retrieved from https://hdl.handle.net/10161/33152.
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Akash Kishore Gupta
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