This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence.

dc.contributor.author

Kwan, Leslie Y

dc.contributor.author

Eaton, David L

dc.contributor.author

Andersen, Susan L

dc.contributor.author

Dow-Edwards, Diana

dc.contributor.author

Levin, Edward D

dc.contributor.author

Talpos, John

dc.contributor.author

Vorhees, Charles V

dc.contributor.author

Li, Abby A

dc.date.accessioned

2023-12-06T16:26:48Z

dc.date.available

2023-12-06T16:26:48Z

dc.date.issued

2020-09

dc.date.updated

2023-12-06T16:26:47Z

dc.description.abstract

Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, that brought together experts in research on drug dependence and toxicity related to nicotine, cannabis, cocaine, and other illicit drugs during adolescence. The goal of the workshop was to address the following issues: (1) Do the effects of adolescent exposure differ from the same exposure in adults? (2) Are there unique biological markers of adolescent brain development? If so, what are they and how reliable are they? (3) Since multiple factors influence substance use disorder, can we disentangle risk factors for abuse and/or toxicity? What are the underlying biological susceptibilities that lead to dependence and neurotoxicity? What are the social, psychosocial and environmental factors that contribute to abuse susceptibilities? This paper reviews drug policy and national trends in adolescent substance use; the public health consequences of e-cigarettes; rat models of adolescent-onset nicotine self-administration and persisting effects of gestational nicotine; sex-dependent effects of delta-9-tetrahydrocannabinol on adolescent brain-behavior relationships; and translational approaches for identifying adolescent risk factors for transition to drug dependence. There is strong evidence that drug exposure prior to adulthood has longer lasting effects on behavior and the underlying neural circuitry. These effects, which are sex-dependent and influenced by stress, may be candidates as predictors of adolescent vulnerability. A major challenge to determining if adolescents have a unique susceptibility to dependence is whether and to what extent the human data allow distinction between the increased risk due to biological immaturity, an underlying biological susceptibility to dependence, or psychosocial and environmental factors for substance dependence. Factors important to consider for development of animal models include the timing and pattern of exposure as it relates to adolescence; age of assessment, and direct comparison with similar effects following exposures to adults to demonstrate that these effects are unique to adolescence. Here we provide a roadmap for further research into what makes adolescent brain development unique.

dc.identifier

S0892-0362(20)30059-3

dc.identifier.issn

0892-0362

dc.identifier.issn

1872-9738

dc.identifier.uri

https://hdl.handle.net/10161/29499

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Neurotoxicology and teratology

dc.relation.isversionof

10.1016/j.ntt.2020.106916

dc.subject

Brain

dc.subject

Animals

dc.subject

Humans

dc.subject

Substance-Related Disorders

dc.subject

Nicotine

dc.subject

Biological Factors

dc.subject

Adolescent Behavior

dc.subject

Adolescent

dc.subject

Electronic Nicotine Delivery Systems

dc.title

This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence.

dc.type

Journal article

duke.contributor.orcid

Levin, Edward D|0000-0001-7292-8084|0000-0002-5060-9602

pubs.begin-page

106916

pubs.organisational-group

Duke

pubs.organisational-group

Nicholas School of the Environment

pubs.organisational-group

School of Medicine

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Pharmacology & Cancer Biology

pubs.organisational-group

Psychiatry & Behavioral Sciences

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Psychology & Neuroscience

pubs.organisational-group

Environmental Sciences and Policy

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Initiatives

pubs.organisational-group

Duke Science & Society

pubs.organisational-group

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

pubs.publication-status

Published

pubs.volume

81

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Kwan et al., 2020_NTT_This is your teen brain on drugs.pdf
Size:
900.61 KB
Format:
Adobe Portable Document Format
Description:
Published version