A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine.
dc.contributor.author | Tarbet, Heather J | |
dc.contributor.author | Toleman, Clifford A | |
dc.contributor.author | Boyce, Michael | |
dc.date.accessioned | 2020-01-01T16:57:49Z | |
dc.date.available | 2020-01-01T16:57:49Z | |
dc.date.issued | 2018-01 | |
dc.date.updated | 2020-01-01T16:57:49Z | |
dc.description.abstract | O-Linked β-N-acetylglucosamine (O-GlcNAc) is a critical post-translational modification (PTM) of thousands of intracellular proteins. Reversible O-GlcNAcylation governs many aspects of cell physiology and is dysregulated in numerous human diseases. Despite this broad pathophysiological significance, major aspects of O-GlcNAc signaling remain poorly understood, including the biochemical mechanisms through which O-GlcNAc transduces information. Recent work from many laboratories, including our own, has revealed that O-GlcNAc, like other intracellular PTMs, can control its substrates' functions by inhibiting or inducing protein-protein interactions. This dynamic regulation of multiprotein complexes exerts diverse downstream signaling effects in a range of processes, cell types, and organisms. Here, we review the literature about O-GlcNAc-regulated protein-protein interactions and suggest important questions for future studies in the field. | |
dc.identifier.issn | 0006-2960 | |
dc.identifier.issn | 1520-4995 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.ispartof | Biochemistry | |
dc.relation.isversionof | 10.1021/acs.biochem.7b00871 | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Acetylglucosamine | |
dc.subject | Biochemistry | |
dc.subject | Signal Transduction | |
dc.subject | Protein Processing, Post-Translational | |
dc.subject | Aminoacylation | |
dc.subject | Models, Biological | |
dc.subject | Protein Interaction Domains and Motifs | |
dc.subject | Protein Multimerization | |
dc.title | A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine. | |
dc.type | Journal article | |
duke.contributor.orcid | Boyce, Michael|0000-0002-2729-4876 | |
pubs.begin-page | 13 | |
pubs.end-page | 21 | |
pubs.issue | 1 | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Biochemistry | |
pubs.organisational-group | Basic Science Departments | |
pubs.publication-status | Published | |
pubs.volume | 57 |
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