The role of chemotherapy in the treatment of central neurocytoma.

dc.contributor.author

Johnson, Margaret O

dc.contributor.author

Kirkpatrick, John P

dc.contributor.author

Patel, Mallika P

dc.contributor.author

Desjardins, Annick

dc.contributor.author

Randazzo, Dina M

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Friedman, Henry S

dc.contributor.author

Ashley, David M

dc.contributor.author

Peters, Katherine B

dc.date.accessioned

2020-08-28T19:26:19Z

dc.date.available

2020-08-28T19:26:19Z

dc.date.issued

2019-11-05

dc.date.updated

2020-08-28T19:26:17Z

dc.description.abstract

Aim: Central neurocytoma (CN) is a rare WHO grade II central nervous system (CNS) tumor. This is an update on chemotherapeutic agents used in its treatment. Patients & methods: An institutional review board-approved, chart review of patients seen at our institution resulted in a single case treated with chemotherapy and is herein included. We proceeded with a comprehensive literature review. Results: We identified 18 citations, representing 39 cases of adult and pediatric CN treated with chemotherapy. With the addition of our single case, the total number of recurrent CN patients treated with temozolomide (TMZ) is nine. Conclusion: There exists marked heterogeneity in chemotherapy used to treat CN. TMZ is incorporated into treatment regimens in the setting of tumor recurrence: its role merits further study.

dc.identifier.issn

2045-0907

dc.identifier.issn

2045-0915

dc.identifier.uri

https://hdl.handle.net/10161/21349

dc.language

eng

dc.publisher

Future Medicine Ltd

dc.relation.ispartof

CNS oncology

dc.relation.isversionof

10.2217/cns-2019-0012

dc.subject

Humans

dc.subject

Neurocytoma

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Brain Neoplasms

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Antineoplastic Agents

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Treatment Outcome

dc.title

The role of chemotherapy in the treatment of central neurocytoma.

dc.type

Journal article

duke.contributor.orcid

Johnson, Margaret O|0000-0003-1208-622X

duke.contributor.orcid

Kirkpatrick, John P|0000-0002-4019-0350

duke.contributor.orcid

Randazzo, Dina M|0000-0002-3394-656X

duke.contributor.orcid

Friedman, Henry S|0000-0001-7588-032X

pubs.begin-page

CNS41

pubs.issue

3

pubs.organisational-group

School of Medicine

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Duke Cancer Institute

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Pathology

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Pediatrics

pubs.organisational-group

Medicine, Medical Oncology

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Duke

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Medicine

pubs.organisational-group

Radiation Oncology

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Neurosurgery

pubs.organisational-group

Pediatrics, Neurology

pubs.organisational-group

Neurology, General & Community Neurology

pubs.organisational-group

Neurology

pubs.publication-status

Published

pubs.volume

8

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