PhenX RISING: real world implementation and sharing of PhenX measures.

McCarty, Catherine A

Huggins, Wayne

Aiello, Allison E

Bilder, Robert M

Hariri, Ahmad

Jernigan, Terry L

Newman, Erik

Sanghera, Dharambir K

Strauman, Timothy J

Zeng, Yi

Ramos, Erin M

Junkins, Heather A

PhenX RISING network

England

2017-03-16T22:12:11Z

2017-03-16T22:12:11Z

2014-03-20

BACKGROUND: The purpose of this manuscript is to describe the PhenX RISING network and the site experiences in the implementation of PhenX measures into ongoing population-based genomic studies. METHODS: Eighty PhenX measures were implemented across the seven PhenX RISING groups, thirty-three of which were used at more than two sites, allowing for cross-site collaboration. Each site used between four and 37 individual measures and five of the sites are validating the PhenX measures through comparison with other study measures. Self-administered and computer-based administration modes are being evaluated at several sites which required changes to the original PhenX Toolkit protocols. A network-wide data use agreement was developed to facilitate data sharing and collaboration. RESULTS: PhenX Toolkit measures have been collected for more than 17,000 participants across the PhenX RISING network. The process of implementation provided information that was used to improve the PhenX Toolkit. The Toolkit was revised to allow researchers to select self- or interviewer administration when creating the data collection worksheets and ranges of specimens necessary to run biological assays has been added to the Toolkit. CONCLUSIONS: The PhenX RISING network has demonstrated that the PhenX Toolkit measures can be implemented successfully in ongoing genomic studies. The next step will be to conduct gene/environment studies.

https://www.ncbi.nlm.nih.gov/pubmed/24650325

1755-8794-7-16

1755-8794

https://hdl.handle.net/10161/13831

eng

Springer Science and Business Media LLC

BMC Med Genomics

10.1186/1755-8794-7-16

Adult

Aged

Asian Continental Ancestry Group

Child

China

Cognition

Diabetes Mellitus

Female

Gene-Environment Interaction

Humans

India

Longitudinal Studies

Male

Middle Aged

Phenotype

Precision Medicine

Surveys and Questionnaires

United States

PhenX RISING: real world implementation and sharing of PhenX measures.

Journal article

Strauman, Timothy J|0000-0002-0310-4505

https://www.ncbi.nlm.nih.gov/pubmed/24650325

16

Center for Child and Family Policy

Center for Population Health & Aging

Center for the Study of Aging and Human Development

Clinical Science Departments

Duke

Duke Institute for Brain Sciences

Duke Population Research Center

Duke Population Research Institute

Duke Science & Society

Duke-UNC Center for Brain Imaging and Analysis

Initiatives

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Geriatrics

Psychiatry & Behavioral Sciences

Psychology and Neuroscience

Sanford School of Public Policy

School of Medicine

Trinity College of Arts & Sciences

University Institutes and Centers

Published online

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