Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity.
| dc.contributor.author | Wagner, Jason | |
| dc.contributor.author | Garcia-Rodriguez, Victor | |
| dc.contributor.author | Yu, Abraham | |
| dc.contributor.author | Dutra, Barbara | |
| dc.contributor.author | Larson, Scott | |
| dc.contributor.author | Cash, Brooks | |
| dc.contributor.author | DuPont, Andrew | |
| dc.contributor.author | Farooq, Ahmad | |
| dc.date.accessioned | 2021-05-28T02:19:04Z | |
| dc.date.available | 2021-05-28T02:19:04Z | |
| dc.date.issued | 2021-05-13 | |
| dc.date.updated | 2021-05-28T02:19:03Z | |
| dc.description.abstract | Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55-16.89; p = 0.007), 4.71 (95% CI: 1.51-14.69; p = 0.01) and 4.12 (95% CI: 1.21-14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality (p = 0.02), hypotension (p = 0.03), and need for vasopressors (p = 0.02), intubation (p = 0.01) and hemodialysis (p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19. | |
| dc.identifier | 10.1038/s41598-021-89340-y | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | Sci Rep | |
| dc.relation.isversionof | 10.1038/s41598-021-89340-y | |
| dc.title | Elevated transaminases and hypoalbuminemia in Covid-19 are prognostic factors for disease severity. | |
| dc.type | Journal article | |
| pubs.begin-page | 10308 | |
| pubs.issue | 1 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Medicine, Gastroenterology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.publication-status | Published online | |
| pubs.volume | 11 |