Murine V kappa gene expression does not follow the VH paradigm.

Kaushik, A

Schulze, DH

Bona, C

Kelsoe, G

United States

2016-01-08T18:07:45Z

1989-05-01

V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.

http://www.ncbi.nlm.nih.gov/pubmed/2497227

0022-1007

https://hdl.handle.net/10161/11491

eng

Rockefeller University Press

J Exp Med

Animals

Animals, Newborn

DNA Probes

Gene Expression Regulation

Genes, Immunoglobulin

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Mice

Mice, Inbred C57BL

Nucleic Acid Hybridization

Murine V kappa gene expression does not follow the VH paradigm.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/2497227

1859

1864

5

Basic Science Departments

Duke

Duke Cancer Institute

Duke Human Vaccine Institute

Immunology

Institutes and Centers

School of Medicine

Published

169