Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals.
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2017-06
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Abstract
Background
Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD.Objectives
This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation.Methods
From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health evaluations, 134 had persistent depressive symptoms (Beck Depression Inventory - BDI ≥ 10, BDI+) and 1,374 had negative symptoms at both time points (BDI-). All participants had been submitted to repeated clinical and laboratory evaluations at a regular follow-up with an average of 26 months from baseline. Low-grade inflammation was defined as plasma high-sensitivity C-Reactive Protein (CRP) concentrations > 3 mg/L. The outcome was the incidence of low-grade inflammation evaluated by the time of the second clinical evaluation.Results
The incidence of low-grade inflammation was more frequently observed in the BDI+ group compared to the BDI- group (20.9% vs. 11.4%; p = 0.001). After adjusting for sex, age, waist circumference, body mass index, levels of physical activity, smoking, and prevalence of metabolic syndrome, persistent depressive symptoms remained an independent predictor of low-grade inflammation onset (OR = 1.76; 95% CI: 1.03-3.02; p = 0.04).Conclusions
Persistent depressive symptoms were independently associated with low-grade inflammation onset among healthy individuals.Type
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Franco, Fábio Gazelato de Mello, Antonio Gabriele Laurinavicius, Paulo A Lotufo, Raquel D Conceição, Fernando Morita, Marcelo Katz, Maurício Wajngarten, José Antonio Maluf Carvalho, et al. (2017). Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals. Arquivos brasileiros de cardiologia, 109(2). p. 0. 10.5935/abc.20170080 Retrieved from https://hdl.handle.net/10161/29910.
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