Signaling Pathways Controlling Microglia Chemotaxis.

Loading...
Thumbnail Image

Date

2017-03-17

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

92
views
16
downloads

Citation Stats

Abstract

Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.14348/molcells.2017.0011

Publication Info

Fan, Yang, Lirui Xie and Chang Y Chung (2017). Signaling Pathways Controlling Microglia Chemotaxis. Molecules and cells, 40(3). pp. 163–168. 10.14348/molcells.2017.0011 Retrieved from https://hdl.handle.net/10161/21063.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.