Closed-Loop Deep Brain Stimulation in Parkinson’s Disease with Distributed, Proportional plus Integral Control

Loading...
Thumbnail Image

Date

2022

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

39
views
27
downloads

Abstract

Continuous deep brain stimulation (cDBS) of either subthalamic nucleus (STN) or globus pallidus (GP) is an effective therapy in Parkinson’s Disease (PD) but is inherently limited by lack of responsiveness to dynamic, fluctuating symptoms intrinsic to the disease. Adaptive DBS (aDBS) adjusts stimulation in response to neural biomarkers to improve both efficacy and battery life. This thesis discusses 1) the development of dual target STN+GP aDBS with a novel, external adaptive controller and 2) the outcomes from a first in-human clinical trial in PD patients (n = 6; NCT #03815656) in order to assess efficacy of the aDBS controller.We performed random amplitude experiments to probe system dynamics and thus estimated initial aDBS parameters. We then implemented an innovative proportional plus integral (PI) aDBS using a novel distributed architecture. The PI aDBS controller was first evaluated in the clinic settings and then compared to cDBS in the home settings. The results showed that the PI aDBS control reduced average power delivered while preserving improved Unified Parkinson’s Disease Rating Scale (UPDRS) III scores in the clinic and reduced beta oscillations during blinded testing in the home setting. Thus, we demonstrated that the novel PI aDBS may enhance chronic, symptomatic treatment of PD.

Description

Provenance

Citation

Citation

Chowdhury, Afsana Hoque (2022). Closed-Loop Deep Brain Stimulation in Parkinson’s Disease with Distributed, Proportional plus Integral Control. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/26890.

Collections


Except where otherwise noted, student scholarship that was shared on DukeSpace after 2009 is made available to the public under a Creative Commons Attribution / Non-commercial / No derivatives (CC-BY-NC-ND) license. All rights in student work shared on DukeSpace before 2009 remain with the author and/or their designee, whose permission may be required for reuse.