Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
dc.contributor.author | Zhang, Yan | |
dc.contributor.author | Wang, Meng-Yun | |
dc.contributor.author | He, Jing | |
dc.contributor.author | Wang, Jiu-Cun | |
dc.contributor.author | Yang, Ya-Jun | |
dc.contributor.author | Jin, Li | |
dc.contributor.author | Chen, Zhi-Yu | |
dc.contributor.author | Ma, Xue-Jun | |
dc.contributor.author | Sun, Meng-Hong | |
dc.contributor.author | Xia, Kai-Qin | |
dc.contributor.author | Hong, Xiao-Nan | |
dc.contributor.author | Wei, Qing-Yi | |
dc.contributor.author | Zhou, Xiao-Yan | |
dc.date.accessioned | 2019-02-01T15:10:31Z | |
dc.date.available | 2019-02-01T15:10:31Z | |
dc.date.issued | 2012-01 | |
dc.date.updated | 2019-02-01T15:10:31Z | |
dc.description.abstract | BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population. METHOD: We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS: We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL (adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes. CONCLUSIONS: The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results. | |
dc.identifier | PONE-D-12-02163 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.relation.ispartof | PloS one | |
dc.relation.isversionof | 10.1371/journal.pone.0037846 | |
dc.subject | Humans | |
dc.subject | Lymphoma, Non-Hodgkin | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Case-Control Studies | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Apoptosis Regulatory Proteins | |
dc.subject | Young Adult | |
dc.title | Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study. | |
dc.type | Journal article | |
duke.contributor.orcid | Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439 | |
pubs.begin-page | e37846 | |
pubs.issue | 5 | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Population Health Sciences | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Medicine, Medical Oncology | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.publication-status | Published | |
pubs.volume | 7 |
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