Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.

dc.contributor.author

Zhang, Yan

dc.contributor.author

Wang, Meng-Yun

dc.contributor.author

He, Jing

dc.contributor.author

Wang, Jiu-Cun

dc.contributor.author

Yang, Ya-Jun

dc.contributor.author

Jin, Li

dc.contributor.author

Chen, Zhi-Yu

dc.contributor.author

Ma, Xue-Jun

dc.contributor.author

Sun, Meng-Hong

dc.contributor.author

Xia, Kai-Qin

dc.contributor.author

Hong, Xiao-Nan

dc.contributor.author

Wei, Qing-Yi

dc.contributor.author

Zhou, Xiao-Yan

dc.date.accessioned

2019-02-01T15:10:31Z

dc.date.available

2019-02-01T15:10:31Z

dc.date.issued

2012-01

dc.date.updated

2019-02-01T15:10:31Z

dc.description.abstract

BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population. METHOD: We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS: We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR = 3.03; 95% CI = 1.68-5.45 for TT vs. CC and adjusted OR = 2.03; 95% CI = 1.53-2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40-60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was elevated for CT/TT genotypes (adjusted OR = 1.95, 95% CI = 1.41-2.70 for B cell NHL and adjusted OR = 2.22, 95% CI = 1.49-3.30 for T cell NHL), particularly for DLBCL (adjusted OR = 2.01, 95%CI = 1.41-2.85) and FL (adjusted OR = 2.53, 95% CI = 1.17-5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes. CONCLUSIONS: The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results.

dc.identifier

PONE-D-12-02163

dc.identifier.issn

1932-6203

dc.identifier.issn

1932-6203

dc.identifier.uri

https://hdl.handle.net/10161/17979

dc.language

eng

dc.publisher

Public Library of Science (PLoS)

dc.relation.ispartof

PloS one

dc.relation.isversionof

10.1371/journal.pone.0037846

dc.subject

Humans

dc.subject

Lymphoma, Non-Hodgkin

dc.subject

Genetic Predisposition to Disease

dc.subject

Case-Control Studies

dc.subject

Polymorphism, Single Nucleotide

dc.subject

Adolescent

dc.subject

Adult

dc.subject

Aged

dc.subject

Aged, 80 and over

dc.subject

Middle Aged

dc.subject

Asian Continental Ancestry Group

dc.subject

Female

dc.subject

Male

dc.subject

Apoptosis Regulatory Proteins

dc.subject

Young Adult

dc.title

Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.

dc.type

Journal article

duke.contributor.orcid

Wei, Qing-Yi|0000-0002-3845-9445|0000-0003-4115-4439

pubs.begin-page

e37846

pubs.issue

5

pubs.organisational-group

School of Medicine

pubs.organisational-group

Duke

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Population Health Sciences

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Medicine, Medical Oncology

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

7

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.pdf
Size:
103.41 KB
Format:
Adobe Portable Document Format