Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations.

dc.contributor.author

Vann, Christopher G

dc.contributor.author

Sexton, Casey L

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Osburn, Shelby C

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Smith, Morgan A

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Haun, Cody T

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Rumbley, Melissa N

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Mumford, Petey W

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Montgomery, Nathan T

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Ruple, Bradley A

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McKendry, James

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Mcleod, Jonathan

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Bashir, Adil

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Beyers, Ronald J

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Brook, Matthew S

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Smith, Kenneth

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Atherton, Philip J

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Beck, Darren T

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McDonald, James R

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Young, Kaelin C

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Phillips, Stuart M

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Roberts, Michael D

dc.date.accessioned

2024-01-11T17:17:16Z

dc.date.available

2024-01-11T17:17:16Z

dc.date.issued

2022-01

dc.description.abstract

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were performed on muscle tissue after study completion. Two-way within-subject repeated measures ANOVAs were performed on most dependent variables, and tracer data were compared using dependent samples t-tests. A significant interaction existed for VL muscle cross-sectional area (assessed via magnetic resonance imaging; interaction p = 0.046), where HV increased this metric from PRE to POST (+3.2%, p = 0.018) whereas HL training did not (-0.1%, p = 0.475). Additionally, HL increased leg extensor strength more so than HV training (interaction p = 0.032; HV < HL at POST and POSTPR, p < 0.025 for each). Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates. No interactions existed for other strength, VL morphology variables, or the relative abundances of major muscle proteins. Compared to HL training, 6 weeks of HV training in previously trained men optimizes VL hypertrophy in lieu of enhanced iNon-MyoPS rates, and this warrants future research.

dc.identifier.issn

1664-042X

dc.identifier.issn

1664-042X

dc.identifier.uri

https://hdl.handle.net/10161/29751

dc.language

eng

dc.publisher

Frontiers Media SA

dc.relation.ispartof

Frontiers in physiology

dc.relation.isversionof

10.3389/fphys.2022.857555

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

higher-load resistance training

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higher-volume resistance training

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muscle hypertrophy

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myofibrillar protein

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non-myofibrillar protein

dc.title

Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations.

dc.type

Journal article

pubs.begin-page

857555

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Staff

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Center for the Study of Aging and Human Development

pubs.publication-status

Published

pubs.volume

13

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