Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.
dc.contributor.author | Schrott, Rose | |
dc.contributor.author | Murphy, Susan K | |
dc.contributor.author | Modliszewski, Jennifer L | |
dc.contributor.author | King, Dillon E | |
dc.contributor.author | Hill, Bendu | |
dc.contributor.author | Itchon-Ramos, Nilda | |
dc.contributor.author | Raburn, Douglas | |
dc.contributor.author | Price, Thomas | |
dc.contributor.author | Levin, Edward D | |
dc.contributor.author | Vandrey, Ryan | |
dc.contributor.author | Corcoran, David L | |
dc.contributor.author | Kollins, Scott H | |
dc.contributor.author | Mitchell, John T | |
dc.date.accessioned | 2023-07-01T14:03:19Z | |
dc.date.available | 2023-07-01T14:03:19Z | |
dc.date.issued | 2021-01 | |
dc.date.updated | 2023-07-01T14:03:17Z | |
dc.description.abstract | Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one spermatogenic cycle). Users and controls did not significantly differ by demographics or semen analyses. Whole-genome bisulfite sequencing identified 163 CpG sites with significantly different DNA methylation in sperm between groups (P < 2.94 × 10-9). Genes associated with altered CpG sites were enriched with those involved in development, including cardiogenesis and neurodevelopment. Many of the differences in sperm DNA methylation between groups were diminished after cannabis abstinence. These results indicate that sustained cannabis abstinence significantly reduces the number of sperm showing cannabis-associated alterations at genes important for early development. | |
dc.identifier | dvab009 | |
dc.identifier.issn | 2058-5888 | |
dc.identifier.issn | 2058-5888 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartof | Environmental epigenetics | |
dc.relation.isversionof | 10.1093/eep/dvab009 | |
dc.subject | DNA methylation | |
dc.subject | cannabis | |
dc.subject | development | |
dc.subject | epigenetics | |
dc.subject | sperm | |
dc.title | Refraining from use diminishes cannabis-associated epigenetic changes in human sperm. | |
dc.type | Journal article | |
duke.contributor.orcid | Murphy, Susan K|0000-0001-8298-7272 | |
duke.contributor.orcid | Raburn, Douglas|0000-0002-7984-1245 | |
duke.contributor.orcid | Price, Thomas|0000-0003-1888-306X | |
duke.contributor.orcid | Levin, Edward D|0000-0002-5060-9602 | |
duke.contributor.orcid | Kollins, Scott H|0000-0001-6847-6935 | |
duke.contributor.orcid | Mitchell, John T|0000-0002-9586-3823 | |
pubs.begin-page | dvab009 | |
pubs.issue | 1 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Nicholas School of the Environment | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Trinity College of Arts & Sciences | |
pubs.organisational-group | Student | |
pubs.organisational-group | Nicholas | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Pharmacology & Cancer Biology | |
pubs.organisational-group | Obstetrics and Gynecology | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Psychiatry & Behavioral Sciences | |
pubs.organisational-group | Obstetrics and Gynecology, Reproductive Endocrinology & Fertility | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Psychology & Neuroscience | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Environmental Sciences and Policy | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Duke Institute for Brain Sciences | |
pubs.organisational-group | Psychiatry, Child & Family Mental Health & Community Psychiatry | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Duke Science & Society | |
pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
pubs.organisational-group | Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology | |
pubs.organisational-group | Obstetrics and Gynecology, Reproductive Sciences | |
pubs.publication-status | Published | |
pubs.volume | 7 |
Files
Original bundle
- Name:
- Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.pdf
- Size:
- 1.09 MB
- Format:
- Adobe Portable Document Format