Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit All?
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2024-09
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Abstract
In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis parameters was poor in older women.
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Advani, Sonali D, Rebecca North, Nicholas A Turner, Sahra Ahmadi, Julia Denniss, Adero Francis, Rachel Johnson, Anum Hasan, et al. (2024). Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit All?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 79(3). pp. 600–603. 10.1093/cid/ciae230 Retrieved from https://hdl.handle.net/10161/32212.
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Sonali Advani
Dr. Advani is an Adjunct Associate Professor of Medicine at Duke University School of Medicine. In July 2024, she joined GSK/ViiV Healthcare as a scientific leadership physician with cross functional experience across global medical affairs as well as Research & Development in HIV therapeutics and vaccines.
Prior to this, she served as a physician investigator in the Duke Center for Antimicrobial Stewardship and Infection Prevention, a Fellow in Implementation Science at HIGH IRI (HIV, Infectious Disease and Global Health Implementation Research) Institute at Washington University, St Louis and Associate Medical Director of Infection Prevention at Yale New Haven Hospital. Her research focused on improving the diagnosis of UTIs in older adults, implementation of diagnostic stewardship interventions, and de-prescribing antibiotics for asymptomatic bacteriuria. She was awarded the K12 Urologic Career Development Award, Pepper Center Career Development Award, and SHEA Research Scholar Award to continue her UTI related research. In addition, she was one of the key investigators for CDC Prevention Epicenter Program and CDC SHEPheRD Contract for the Use of Race, Ethnicity, and Social Determinants of Health Data in NHSN Measures to Promote Health Equity.
Rebecca North
Rebecca North, PhD
Dr. North is a collaborative biostatistician who lets clinical application drive methodological innovation. This has been true since graduate school at NC State University, where her dissertation focused on variable selection methods for functional data for the purpose of identifying a sparse set of electromyogram signals that would accurately predict the velocity of a prosthetic arm. Also while in graduate school, Dr. North was supported by a T32 Traineeship, the National Heart, Lung, and Blood Institute Integrated Biostatistical Training Program for Cardiovascular Disease Research, through which she gained clinical research experience at the Duke Clinical Research Institute with particular focus on atrial fibrillation research.
Since joining the Duke Aging Center, Dr. North has gained statistical experience in latent class analysis, mediation analysis, and meta-analysis, to add to her knowledge of functional data analysis, variable selection techniques, random forests and decision trees, survival analysis, longitudinal data analysis, and other classical frequentist statistical methods. Her clinical areas of interest include circadian rhythm research, cardiovascular research (particularly atrial fibrillation), and Veteran health.
Kenneth Edwin Schmader
Dr. Schmader’s areas of research include herpes zoster, infections, and vaccines in older adults. He conducts translational, clinical trials and observational studies of zoster, influenza, and other infections funded by grants from the National Institute on Aging (NIA), National Institute of Allergy and Infectious Diseases (NIAID), Centers for Disease Control (CDC), VA Office of Research and Development, and Industry sources. He has played a pivotal role in the development of zoster vaccines in older adults. Dr. Schmader also performs research in medications and older adults, focusing on pharmacoepidemiology, optimal drug use and reduction of adverse drug reactions.
He is the Director of the NIA-funded P30 Duke Pepper Older Americans Independence Center, Co-investigator of the NIAID funded Collaborative Influenza Vaccine Innovation Centers (CIVICS) and the CDC Clinical Immunization Safety Assessment (CISA) office at Duke. He serves on the Working Groups for the Herpes Zoster, Influenza, COVID-19, RSV and General Adult Immunization Guidelines for the US Centers for Disease Control (CDC) Advisory Committee on Immunization Practices (ACIP) and is the American Geriatrics Society liaison to the ACIP.
Deverick John Anderson
Hospital epidemiology, infection control, antibiotic stewardship, multidrug-resistant organisms, device-related infections, surgical site infections, catheter-associated bloodstream infections, cost of infections, infections in community hospitals
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