Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

dc.contributor.author

deSouza, NM

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Winfield, JM

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Waterton, JC

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Weller, A

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Papoutsaki, M-V

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Doran, SJ

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Collins, DJ

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Fournier, L

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Sullivan, D

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Chenevert, T

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Jackson, A

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Boss, M

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Trattnig, S

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Liu, Y

dc.date.accessioned

2019-02-01T15:23:32Z

dc.date.available

2019-02-01T15:23:32Z

dc.date.issued

2018-03

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2019-02-01T15:23:27Z

dc.description.abstract

For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for prognosis, progression or response, quantitative evaluation of the apparent diffusion coefficient (ADC) is required. Validation and qualification of ADC in multicentre trials involves examination of i) technical performance to determine biomarker bias and reproducibility and ii) biological performance to interrogate a specific aspect of biology or to forecast outcome. Unfortunately, the variety of acquisition and analysis methodologies employed at different centres make ADC values non-comparable between them. This invalidates implementation in multicentre trials and limits utility of ADC as a biomarker. This article reviews the factors contributing to ADC variability in terms of data acquisition and analysis. Hardware and software considerations are discussed when implementing standardised protocols across multi-vendor platforms together with methods for quality assurance and quality control. Processes of data collection, archiving, curation, analysis, central reading and handling incidental findings are considered in the conduct of multicentre trials. Data protection and good clinical practice are essential prerequisites. Developing international consensus of procedures is critical to successful validation if ADC is to become a useful biomarker in oncology.• Standardised acquisition/analysis allows quantification of imaging biomarkers in multicentre trials. • Establishing "precision" of the measurement in the multicentre context is essential. • A repository with traceable data of known provenance promotes further research.

dc.identifier

10.1007/s00330-017-4972-z

dc.identifier.issn

0938-7994

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1432-1084

dc.identifier.uri

https://hdl.handle.net/10161/18008

dc.language

eng

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Springer Science and Business Media LLC

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European radiology

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10.1007/s00330-017-4972-z

dc.subject

Humans

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Neoplasms

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Disease Progression

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Diffusion Magnetic Resonance Imaging

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Prognosis

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Prospective Studies

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Reproducibility of Results

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Software

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Quality Assurance, Health Care

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Multicenter Studies as Topic

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Healthy Volunteers

dc.title

Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

dc.type

Journal article

duke.contributor.orcid

Sullivan, D|0000-0002-7556-5650

pubs.begin-page

1118

pubs.end-page

1131

pubs.issue

3

pubs.organisational-group

School of Medicine

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Duke

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Duke Clinical Research Institute

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Institutes and Centers

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Radiology

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Clinical Science Departments

pubs.publication-status

Published

pubs.volume

28

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