Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

Rezvani, Amir H

Wells, Corinne

Hawkey, Andrew

Blair, Graham

Koburov, Reese

Ko, Ashley

Schwartz, Andrea

Kim, Veronica J

Levin, Edward D

2023-12-06T15:09:08Z

2023-12-06T15:09:08Z

2021-10

2023-12-06T15:09:07Z

Opioid use disorder (OUD) has a variety of adverse effects on both the users and their offspring. In the current study, a random group of Sprague-Dawley rats (25 females and 15 males) were tested for intravenous self-administration of the opioid agonist remifentanil to determine the range of acquisition for opioid. One-month after the end of self-administration of remifentanil, rats with the highest intake were mated together and rats with lowest intake were mated together. Then, the offspring of the two groups were tested for anxiety-like behavior, locomotor activity, nociception and intravenous remifentanil self-administration. The parents showed a range of remifentanil self-administration, especially in the female rats. The offspring of the parents with low and high remifentanil self-administration showed significant differences in specific behavioral functions. On the hotplate test of nociception, the female offspring parents with high remifentanil self-administration had significantly longer hotplate latencies, indicating reduced nociception, than the female offspring of parents with low remifentanil-self-administration, whereas there was no difference in the male offspring of low and high responding parents. In the elevated plus maze test of anxiety-like behavior, the offspring of the parents with high remifentanil intake showed more anxiety-like behavior than the offspring of the parents with low remifentanil intake regardless of sex. Locomotor activity was not significantly different. Interestingly, no significant differences in remifentanil self-administration in the offspring of parents with low and high remifentanil self-administration were detected. Overall, our data suggest a considerable range in remifentanil self-administration in rats and the offspring of rats with high opioid self-administration exhibit different behaviors vs offspring of rats with low opioid self-administration.

S0014-2999(21)00560-4

0014-2999

1879-0712

https://hdl.handle.net/10161/29486

eng

Elsevier BV

European journal of pharmacology

10.1016/j.ejphar.2021.174407

Animals

Humans

Rats

Opioid-Related Disorders

Disease Models, Animal

Analgesics, Opioid

Self Administration

Behavior, Animal

Maternal Exposure

Paternal Exposure

Dose-Response Relationship, Drug

Female

Male

Remifentanil

Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

Journal article

Levin, Edward D|0000-0001-7292-8084|0000-0002-5060-9602

174407

Duke

Nicholas School of the Environment

School of Medicine

Trinity College of Arts & Sciences

Basic Science Departments

Clinical Science Departments

Institutes and Centers

Pharmacology & Cancer Biology

Psychiatry & Behavioral Sciences

Duke Cancer Institute

Psychology & Neuroscience

Environmental Sciences and Policy

Institutes and Provost's Academic Units

University Institutes and Centers

Duke Institute for Brain Sciences

Initiatives

Duke Science & Society

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

Published

909