Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

dc.contributor.author

Rezvani, Amir H

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Wells, Corinne

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Hawkey, Andrew

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Blair, Graham

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Koburov, Reese

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Ko, Ashley

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Schwartz, Andrea

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Kim, Veronica J

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Levin, Edward D

dc.date.accessioned

2023-12-06T15:09:08Z

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2023-12-06T15:09:08Z

dc.date.issued

2021-10

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2023-12-06T15:09:07Z

dc.description.abstract

Opioid use disorder (OUD) has a variety of adverse effects on both the users and their offspring. In the current study, a random group of Sprague-Dawley rats (25 females and 15 males) were tested for intravenous self-administration of the opioid agonist remifentanil to determine the range of acquisition for opioid. One-month after the end of self-administration of remifentanil, rats with the highest intake were mated together and rats with lowest intake were mated together. Then, the offspring of the two groups were tested for anxiety-like behavior, locomotor activity, nociception and intravenous remifentanil self-administration. The parents showed a range of remifentanil self-administration, especially in the female rats. The offspring of the parents with low and high remifentanil self-administration showed significant differences in specific behavioral functions. On the hotplate test of nociception, the female offspring parents with high remifentanil self-administration had significantly longer hotplate latencies, indicating reduced nociception, than the female offspring of parents with low remifentanil-self-administration, whereas there was no difference in the male offspring of low and high responding parents. In the elevated plus maze test of anxiety-like behavior, the offspring of the parents with high remifentanil intake showed more anxiety-like behavior than the offspring of the parents with low remifentanil intake regardless of sex. Locomotor activity was not significantly different. Interestingly, no significant differences in remifentanil self-administration in the offspring of parents with low and high remifentanil self-administration were detected. Overall, our data suggest a considerable range in remifentanil self-administration in rats and the offspring of rats with high opioid self-administration exhibit different behaviors vs offspring of rats with low opioid self-administration.

dc.identifier

S0014-2999(21)00560-4

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0014-2999

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1879-0712

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https://hdl.handle.net/10161/29486

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

European journal of pharmacology

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10.1016/j.ejphar.2021.174407

dc.subject

Animals

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Humans

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Rats

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Opioid-Related Disorders

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Disease Models, Animal

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Analgesics, Opioid

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Self Administration

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Behavior, Animal

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Maternal Exposure

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Paternal Exposure

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Dose-Response Relationship, Drug

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Female

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Male

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Remifentanil

dc.title

Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

dc.type

Journal article

duke.contributor.orcid

Levin, Edward D|0000-0001-7292-8084|0000-0002-5060-9602

pubs.begin-page

174407

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Duke

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Nicholas School of the Environment

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School of Medicine

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Trinity College of Arts & Sciences

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Pharmacology & Cancer Biology

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Psychiatry & Behavioral Sciences

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Duke Cancer Institute

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Psychology & Neuroscience

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Environmental Sciences and Policy

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Institute for Brain Sciences

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Initiatives

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Duke Science & Society

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Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

pubs.publication-status

Published

pubs.volume

909

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