A Multi-Center International Analysis of Lung Transplantation Outcomes in Patients With COVID-19.
dc.contributor.author | Kashem, Mohammed Abul | |
dc.contributor.author | Loor, Gabriel | |
dc.contributor.author | Emtiazjoo, Amir | |
dc.contributor.author | Hartwig, Matthew | |
dc.contributor.author | Van Raemdonck, Dirk | |
dc.contributor.author | Calvelli, Hannah | |
dc.contributor.author | Leon Pena, Andres | |
dc.contributor.author | Salan-Gomez, Marcelo | |
dc.contributor.author | Zhao, Huaqing | |
dc.contributor.author | Warnick, Michael | |
dc.contributor.author | Villavicencio, Mauricio | |
dc.contributor.author | Ius, Fabio | |
dc.contributor.author | Ghadimi, Kamrouz | |
dc.contributor.author | Salman, Jawad | |
dc.contributor.author | Chandrashekaran, Satish | |
dc.contributor.author | Machuca, Tiago | |
dc.contributor.author | Sanchez, Pablo G | |
dc.contributor.author | Subramaniam, Kathirvel | |
dc.contributor.author | Neyrinck, Arne | |
dc.contributor.author | Huddleston, Stephen | |
dc.contributor.author | Ceulemans, Laurens | |
dc.contributor.author | Osho, Asishana | |
dc.contributor.author | D'Silva, Ethan | |
dc.contributor.author | Ramamurthy, Uma | |
dc.contributor.author | Shaffer, Andrew | |
dc.contributor.author | Langer, Nathaniel | |
dc.contributor.author | Toyoda, Yoshiya | |
dc.date.accessioned | 2024-12-08T19:50:49Z | |
dc.date.available | 2024-12-08T19:50:49Z | |
dc.date.issued | 2024-09 | |
dc.description.abstract | IntroductionLung transplantation has become increasingly utilized in patients with COVID-19. While several single-center and UNOS database studies have been published on lung transplants (LTs) for end-stage lung disease (ESLD) from Coronavirus disease 2019 (COVID-19), there is a lack of multi-center and international data.MethodsThis is a multicenter analysis from 11 high-volume lung transplant centers in the United States and Europe. Data were collected through the Multi-Institutional ECLS Registry and stratified by ESLD due to COVID-19 versus other etiologies. Demographics and clinical variables were compared using Chi-square test and Fisher's exact test. Survival was assessed by Kaplan-Meier curves and compared by log-rank test with propensity score matching.ResultsOf 1606 lung transplant recipients, 46 (2.9%) were transplanted for ESLD from COVID-19 compared to 1560 (97.1%) without a history of COVID-19. Among COVID-19 patients, 30 (65.2%) had COVID-19-associated ARDS and 16 (34.8%) had post-COVID-19 fibrosis. COVID-19 patients had higher lung allocation scores (78.0 vs. 44.4, p < 0.0001), had severely limited functional status (37.0% vs. 2.9%, p < 0.0001), had higher preoperative ECMO usage (65.2% vs. 5.4%, p < 0.0001), and spent less time on the waitlist (32 vs. 137 days, p < 0.0001). A 30-day survival was comparable between COVID-19 and non-COVID-19 patients before (100% vs. 98.7%, p = 0.39) and after propensity matching (p = 0.15).ConclusionsPatients who received LTs due to COVID-19 had short-term survival comparable to that of patients without COVID-19. Our findings support the idea that lung transplantation should be considered for select patients with ESLD due to COVID-19. | |
dc.identifier.issn | 0902-0063 | |
dc.identifier.issn | 1399-0012 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Clinical transplantation | |
dc.relation.isversionof | 10.1111/ctr.15462 | |
dc.rights.uri | ||
dc.subject | Humans | |
dc.subject | Treatment Outcome | |
dc.subject | Lung Transplantation | |
dc.subject | Registries | |
dc.subject | Survival Rate | |
dc.subject | Retrospective Studies | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | United States | |
dc.subject | Europe | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | COVID-19 | |
dc.subject | SARS-CoV-2 | |
dc.title | A Multi-Center International Analysis of Lung Transplantation Outcomes in Patients With COVID-19. | |
dc.type | Journal article | |
duke.contributor.orcid | Hartwig, Matthew|0000-0001-8393-2791 | |
duke.contributor.orcid | Ghadimi, Kamrouz|0000-0002-9287-7541 | |
pubs.begin-page | e15462 | |
pubs.issue | 9 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Biomedical Engineering | |
pubs.organisational-group | Anesthesiology | |
pubs.organisational-group | Anesthesiology, Cardiothoracic | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
pubs.publication-status | Published | |
pubs.volume | 38 |