Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review.

dc.contributor.author

Wang, Sheng-Min

dc.contributor.author

Han, Changsu

dc.contributor.author

Bahk, Won-Myoung

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Lee, Soo-Jung

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Patkar, Ashwin A

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Masand, Prakash S

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Pae, Chi-Un

dc.date.accessioned

2018-12-02T02:08:48Z

dc.date.available

2018-12-02T02:08:48Z

dc.date.issued

2018-05-25

dc.date.updated

2018-12-02T02:08:45Z

dc.description.abstract

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies, including meta-analyses, naturalistic studies, and longer-term studies suggested that SSRIs and SNRIs are no less safe than TCAs. We focused on comparing the common side effects of TCAs with those of newer generation antidepressants including SSRIs, SNRIs, mirtazapine, and bupropion. The main purpose was to investigate safety profile differences among drug classes rather than the individual antidepressants, so studies containing comparison data on drug groups were prioritized. In terms of safety after overdose, the common belief on newer generation antidepressants having fewer side effects than TCAs appears to be true. TCAs were also associated with higher drop-out rates, lower tolerability, and higher cardiac side-effects. However, evidence regarding side effects including dry mouth, gastrointestinal side effects, hepatotoxicity, seizure, and weight has been inconsistent, some studies demonstrated the superiority of SSRIs and SNRIs over TCAs, while others found the opposite. Some other side effects such as sexual dysfunction, bleeding, and hyponatremia were more prominent with either SSRIs or SNRIs.

dc.identifier.issn

2233-7385

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2233-7393

dc.identifier.uri

https://hdl.handle.net/10161/17686

dc.language

eng

dc.publisher

Chonnam National University Medical School

dc.relation.ispartof

Chonnam medical journal

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10.4068/cmj.2018.54.2.101

dc.subject

Antidepressive Agents

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Depressive Disorder

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Drug-related Side Effects and Adverse Reactions

dc.title

Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review.

dc.type

Journal article

pubs.begin-page

101

pubs.end-page

112

pubs.issue

2

pubs.organisational-group

School of Medicine

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Duke

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Psychiatry & Behavioral Sciences, Addictions

pubs.organisational-group

Psychiatry & Behavioral Sciences

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Clinical Science Departments

pubs.organisational-group

Community and Family Medicine, Community Health

pubs.organisational-group

Community and Family Medicine

pubs.publication-status

Published

pubs.volume

54

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